Specific binding assay method and test kit employing polyvinyl a

Details Specific binding assay method and test kit employing polyvinyl a Specific binding assay method and test kit employing polyvinyl a

1977-11-16

1979-08-28

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 206569, 424 12, G01N 3316

Patent

active

041661036

ABSTRACT:
A specific binding assay method and test kit for determining a ligand, particularly an antigen or hapten, in, or the ligand binding capacity of, a liquid medium, particularly a body fluid such as serum, wherein the liquid medium is combined with assay reagent means including a labeled binding component, such as a radiolabeled form of the ligand, with the improvement that separation of the resulting bound-species and free-species of the labeled component is accomplished by selectively adsorbing the free-species onto a solid comprising a nonion-exchange cross-linked polyvinyl alcohol. The method is particularly suited to the radioimmunoassay detection of nonproteinaceous haptens such as thyroxine, triiodothyronine, estriol, vitamin B.sub.12 and digoxin. The polyvinyl alcohol adsorbent provides a very effective and readily available separation means for use in specific binding assays.

REFERENCES:
patent: 4001583 (1977-01-01), Barrett
patent: 4020151 (1977-04-01), Bolz et al.
patent: 4048298 (1977-09-01), Niswender
patent: 4069352 (1978-01-01), Parsons, Jr.
Croll et al., 1st ed. New Techniques in Tumor Location and Radioummunoassay, J. Wiley & Sons, NY, 1975, pp. 9-15.

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