Specific antibody to the native form of 2'5'-oligonucleotides, t

Details Specific antibody to the native form of 2'5'-oligonucleotides, t Specific antibody to the native form of 2'5'-oligonucleotides, t

1988-01-25

1989-04-25

Nucker, Christine M.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Chemical modification or the reaction product thereof, e.g.,...

424 88, 424 858, 435 6, 436548, 530387, 536 27, C07K 1500

Patent

active

048249416

ABSTRACT:
A new specific antibody to 5'-terminal mono-, di- or triphosphorylated (2'-5')adenyl-adenoisine oligonucleotides and a method of producing it have been found. The antibody can be used for the quantitative analysis of the oligonucleotides mentioned above in any one of the well known methods of immunological analysis.

REFERENCES:
Sawai et al., "Characterization of Antibody to 2'-5' Linked Oligoadenylic Acid," Chemical Abstracts, vol. 98, No. 7, Abstract No. 5166b, 1983.
Shinomiya et al., "Preparation and Binding Specificity of an Antibody to 2'-5' Linked Triadenylic Acid," Chemical Abstracts, vol. 98, No. 11, Abstract No. 87340f, 1983.
Cailla et al., "Monoclonal Antibodies to 2-5A Oligonucleotides: Their Use in Radio-Immunoassay of Phosphorylated and Dephosphorylated 25A," Chemical Abstracts, vol. 99, No. 7, Abstract No. 209018a, 1983.
Cailla et al., Proceedings of the National Academy Sciences, U.S.A., vol. 79, pp. 4742-4746, 1982.
Munns et al., Biochemistry, vol. 21, pp. 2929-2936, 1982.

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