Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2003-08-07
2009-06-30
Romeo, David S (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388100, C530S388240, C530S389100, C530S389200, C435S070210
Reexamination Certificate
active
07553937
ABSTRACT:
The invention relates to an in vitro diagnosis of heart failure. More specifically, the invention relates to specific antibodies of a peptide domain which is situated on either side of hinge region R76S77 of proBNP(1-108). In particular, the invention relates to a method of obtaining the aforementioned antibodies and to the use thereof in detecting blood proBNP(1-108) with the exception of BNP(1-76) and BNP(77-108). The invention also relates to a method of detecting blood proBNP(1-108), reagents and a kit for same.
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Goetze, et al., “Quantification of pro-B-type natriuretic peptide and its products in human plasma by use of an analysis independent of precursor processing”, Clinical Chemistry, vol. 48, No. 7, p. 1035-1042, Jul. 2002, [XP001149219].
Giuliani Isabelle
Pau Bernard
Rieunier François
Bio-Rad Pasteur
Centre National de la Recherche Scientifique
Gamett Daniel C
Jacobson & Holman PLLC
Romeo David S
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