Species specific egg-binding proteins of sperm

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 235, 536 2431, 536 2433, 4353201, 530350, C12N 1512

Patent

active

058518177

ABSTRACT:
Disclosed are compositions which bind to mammalian egg zona pellucida in species-specific fashion. Also disclosed are methods for speciating mammalian eggs, identifying species-specific sperm, and providing contraception in a mammalian population. Specifically disclosed are nucleic acid sequences and the corresponding amino acid sequences of specific sperm membrane proteins they encode, whose identification and characterization have permitted development of species-specific contraceptive and fertility compositions and methods.

REFERENCES:
Young, et al., PNAS, vol. 80, Mar. 1983, pp. 1194-1198.
Bliel and Wassarman, "Identification of a ZP3-binding protein on acrosome-intact mouse sperm by photoaffinity crosslinking," Proc. Natl. Acad. Sci. USA, 87:5563-5567, 1990.
Cheng et al., "Sperm-Egg Recognition in the Mouse: Characterization of sp56, A Sperm Protein Having Specific Affinity for ZP3," The Journal of Cell Biology, 125(4):867-878, 1994.
Fernandez et al., "Internal Protein Sequence Analysis: Enzymatic Digestion for Less Than 10 .mu.g of Protein Bound to Polyvinylidene Difluoride or Nitrocellulose Membranes.sup.1," Analytical Biochemistry, 201:255-264, 1992.
Gao et al., "Sequence of mRNA coding for bindin, a species-specific sea urchin sperm protein required for fertilization," Proc. Natl. Acad. Sci. USA, 83:8634-8638, 1986.
Hardy and Garbers, "Molecular Basis of Signaling in Spermatoza," Molecular Biology of the Male Reproductive System, 233-270, 1993.
Hedrick and Hardy, "Isolation of Extracellular Matrix Structures from Xenopus laevis Oocytes, Eggs, and Embryos,m" Methods in Cell Biology, 36:231-247, 1991.
Hilkens et al., "Cell membrane-associated mucins and their ashesion-modulating property," Trends Biochem. Sci., 17:359-363, 1992.
Jonakova et al., "Isolation and biochemical characterization f a zona pellucida-binding glycoprotein of boar spermatozoa," FEBS Letters, 280(1):183-186, 1991.
Kinloch et al., "Genomic Organization and Polypeptide Primary Structure of Zona Pellucida-Glycoprotein hZP3, the Hamster Sperm Receptor," Developmental Biology, 142:414-421, 1990.
Lathrop et al., "cDNA Cloning Reveals the Molecular Structure of A sperm Surface Protein, PH-20, Involved in Sperm-Egg Adhesion And the Wide Distribution of Its Gene among Mammals," The Journal of Cell Biology, 111(6) (Pt. 2):2939-2949, 1990.
Lopez et al., "Evidence for a Molecular Distinction between Golgi and Cell Surface Forms of .beta.1,4-Galactosyltransferase," The Journal of Biological Chemistry, 266(24):15984-15991, 1991.
Macek et al., "Aggregation of .beta.-1,4-Galactosyltransferase on Mouse Sperm Induces the Acrosome Reaction," Developmental Biology, 147:440-444, 1991.
Mayadas and Wagner, "Vicinal cysteines in the prosequence play a role in von Willebrand factor multimer assembly," Proc. Natl. Acad. Sci. USA, 89:3531-3535, 1992.
Miller et al., "Complementarity between sperm surface .beta.-1,4-galactosyl-transferase and egg-coat ZP3 mediates sperm-egg binding," Nature, 357:589-593, 1992.
Minor et al., "Species-Specific Inhibition of Fertilization by a Peptide Derived from the Sperm Protein Bindin," Molecular Biology of the Cell, 4:375-387, 1993.
Minor et al., "Comparison of the Bindin Proteins of Strongylocentrotus franciscanus, S. purpuratus and Lytechinus variegatus: Sequence involved in the Species Specificity of Fertilization," Mol. Biol. Evol., 8(6):781-795, 1991.
Moller et al., "Structural and Functional Relationships between Mouse and Hamster Zona Pellucida Glycoproteins," Developmental Biology, 137:276-286, 1990.
O'Rand et al., "Identification of Zona Binding Proteins of Rabbit, Pig, Human, and Mouse Spermatozoa on Nitrocellulose Blots," The Journal of Experimental Zoology, 235:423-428, 1985.
Parry et al., "Characterization of Low Mr Zona Pellucida Binding Proteins From Boar Spermatozoa and Seminal Plasma," Molecular Reproduction and Development, 33:108-115, 1992.
Peterson et al., "Interaction of Boar Spermatozoa With Porcine Oocytes: Increase in Proteins with High Affinity for the Zona Pellucida During Epididymal Transis," Gamete Research, 14:57-64, 1986.
Primakoff et al., "Identification and Purification of a Sperm Surface Protein with a Potential Role in Sperm-Egg Membrane Fusion," The Journal of Cell Biology, 104:141-149, 1987.
Sacco et al., "Porcine Zona Pellucida: Association of Sperm Receptor Activity with the .alpha.-Glycoprotein Component of the M.sub.r =55,000 Family," Biology of Reproduction, 41:523-532, 1989.
Shur, "Expression and function of cell surface galactosyltransferase," Biochimica et Biophysica Acta., 988:398-409, 1989.
Urch and Patel, "The interaction of boar sperm proacrosin with its natural substrate, the zona pellucida and with polysulfated polysaccharides," Development, 111:1165-1172, 1991.
Vassar et al., "Spatial Segregation of Odorant Receptor Expression in the Mammalian Olfactory Epithelium," Cell, 74:309-318, 1993.
Ward and Kopf, "Molecular Events Mediating Sperm Activation," Developmental Biology, 158:9-34, 1993.
Wassarman, "Zona Pellucida Glycoproteins," Ann. Rev. Biochem., 57:415-42, 1988.
Wassarman, "Mouse Gamete Adhesion Molecule," Biology of Reproduction, 46:186-191, 1992.
Williams and Jones, "Specificity of Binding of Zona Pellucida Glycoproteins to Sperm Proacrosin and Related Proteins," The Journal of Experimental Zoology, 266:65-73, 1993.
Yurewicz et al., "Nucleotide sequence of cDNA encoding ZP3.alpha., a sperm-binding glycoprotein from zona pellucida of pig oocyte," Biochmica et Biophysica Acta, 1174:211-214, 1993.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Species specific egg-binding proteins of sperm does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Species specific egg-binding proteins of sperm, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Species specific egg-binding proteins of sperm will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2046145

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.