Spatially aligned conjugated composition having a thioether bond

Details Spatially aligned conjugated composition having a thioether bond Spatially aligned conjugated composition having a thioether bond

1998-05-15

2000-07-11

Park, Hankyel

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

530324, 42419611, 42419711, 424 153, 424 169, A61K 39385, A61K 3800, A61M 3614, C07K 500

Patent

active

060868813

ABSTRACT:
The present invention is a spatially aligned conjugated composition which comprises at least one chemically modified substance which is immunologically representative of a prechosen infectious agent and provides a chemical constituent for entering into and forming a thioether bond; a plurality of chemically substituted metallic oxide particles which range from about 10-10,000 nanometers and are able to enter into a thioether bond and covalent linkage; and at least one thioether bond and linkage joining the metallic oxide particles in a controlled and spatially aligned manner to the antigen or hapten. The conjugated composition may be alternatively employed as an immunogen; as a vaccine; as a diagnostic tool and reactant; and as an analytical material suitable for testing the pharmacological activity of new compounds.

REFERENCES:
Fahey t al., Status of immune-based therapies in HIV infection and AIDS, Clin. exp. Immunol. 88, 1-5, see p. 3, col. 2, paragraph 3, Jan. 1992.
Fox, J. L., No winners against AIDS, Bio/Tech. vol. 12, 128, see entire page, Feb. 1994.
Frey et al., Peptomer Aluminum Oxide Nanoparticle Conjugates as Systemic and Mucosal Vaccine Candidates: Synthesis and Characterization of a Conjugate Derived from the C4 Domain of HIV-1 gp120., Bioconjugate Chem. 8, 424-433, see entire article, May 1997.

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