Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1981-02-02
1982-05-25
Rizzo, Nicholas S.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424270, 424271, 2602391, C07D49914
Patent
active
043315992
ABSTRACT:
The 1:2 N,N'-dibenzylethylenediamine, the N-benzyl-2-phenylethylamine and the dibenzylamine salts of penicillanic acid 1,1-dioxide, a well-known betalactamase inhibitor, are sparingly soluble in water. Accordingly they are valuable as slow release (depot) forms of penicillanic acid 1,1-dioxide, particularly for use in conjunction with slow release (depot) forms of penicillin and cephalosporin antibiotics, in the chemotherapy of bacterial infections in mammals.
REFERENCES:
patent: 2547782 (1951-04-01), Rhodehamel et al.
patent: 2585432 (1952-02-01), Buckwalter
patent: 2627491 (1953-02-01), Szabo et al.
patent: 4234579 (1980-11-01), Barth
The Merck Index, p. 1005, (1976).
Armstrong William W.
Moppett Charles E.
Windisch Wendell W.
Frost Albert E.
Knuth Charles J.
Lumb J. Trevor
Pfizer Inc.
Rizzo Nicholas S.
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