Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-03-07
2009-12-15
Cheu, Jacob (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C435S007910, C435S007920
Reexamination Certificate
active
07632649
ABSTRACT:
Phosphorylated Sp1 can be used as a marker for in vitro diagnosis of non-alcoholic steatohepatitis (NASH) as well as a therapeutical target of said condition.
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One Way Liver Genomics, S.L., “European Search Report,” May 17, 2006.
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Ihn et al., “Increased Phosphorylation of Transcription Factor Sp1 in Schleroderma Fibroblasts: Association with Increased Expression of the Type I Collagen Gene,” Arthritis and Rheumatism, vol. 43, No. 10, Oct. 2000, pp. 2240-2247.
Black et al., “Growth/Cell Cycle Regulation of Sp1 Phosphorylation,” Journal of Biological Chemistry, vol. 274, No. 3, Jan. 15, 1999, pp. 1207-1215.
Leggett et al., “Sp1 is Phosphorylated and its DNA Binding Activity Down-Regulated Upon Terminal Differentiation of the Liver,” Journal of Biological Chemistry, American Society of Biolochemical BIologists, vol. 270, No. 43, Oct. 27, 1995, pp. 25879-25884.
Lu et al., “Methionine Adenosyltransferase 1A Knockout Mice are Predisposed to Liver Injury and Exhibit Increased Expression of Genes Involved in Proliferation,” Proceedings of the National Academy of Sciences of USA, vol. 98, No. 10, (May 8, 2001), pp. 5560-5565.
Chu et al., “Sp1: Regulation of Gene Expression by Phosphorylation,” Gene, vol. 348, (Mar. 28, 2005), pp. 1-11.
Cheu Jacob
Fuierer Tristan A.
Moore & Van Allen PLLC
One Way Liver Genomics, S.L.
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