Sorbitol, process for its preparation, and use thereof

Details Sorbitol, process for its preparation, and use thereof Sorbitol, process for its preparation, and use thereof

1985-01-23

1986-08-12

Evans, J. E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

424 52, 424 53, 426548, 568863, 568868, C07C 2976, C07C 3126

Patent

active

046057943

ABSTRACT:
A modified sorbitol with improved tableting properties, viz, has a melting point of about 96.degree. C., a bulk density of 0.3-0.6 g/ml, a .gamma.-sorbitol content of at least 90%, a purity of at least 98%, a specific surface area of 0.7-1.5 m.sup.2 /g, a bending strength of at least 7 N/mm.sup.2 at a compressive force of at least 10,000 N, and a friability of less than 1% at a compressive force of at least 10,000 N, can be prepared by obtaining a sorbitol solution by hydrogenation of crystallized glucose at a temperature below 170.degree. C., and spray-drying this solution at a temperature of 140.degree. to 170.degree. C. The sorbitol thus obtained has a water content of less than 1%.
The sorbitol is useful for the production of compressed formulations.

REFERENCES:
patent: 2280975 (1942-04-01), Power
patent: 3329729 (1967-07-01), Brandner et al.
patent: 3484492 (1969-12-01), Hales
patent: 4252794 (1981-02-01), DuRoss
patent: 4292451 (1981-09-01), deBerardinis et al.
patent: 4293570 (1981-10-01), Vadasz
patent: 4380680 (1983-04-01), Arena

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