Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-03-22
2005-03-22
Raymond, Richard L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S241000, C514S252120, C514S252130, C514S255010, C544S242000, C544S295000, C544S326000, C544S194000
Reexamination Certificate
active
06869943
ABSTRACT:
This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I,wherein R1, R2and R3are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds and methods of treating or preventing diabetic complications, particularly diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, diabetic macroangiopathy and diabetic cardiomyopathy by administering such compounds to a mammal suffering from diabetes and therefore at risk for developing such complications. This invention is also directed to pharmaceutical compositions comprising a combination of compound of formula I of this invention with an aldose reductase inhibitor and to methods of treating or preventing diabetic complications therewith. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor and to methods of treating cardiomyopathy and other heart-related problems therewith. This invention is also directed to certain intermediates used in the synthesis of the compounds of formula I and to processes for preparing those intermediates.
REFERENCES:
patent: 5138058 (1992-08-01), Geisen et al.
patent: 5215990 (1993-06-01), Geisen et al.
patent: 5728704 (1998-03-01), Mylari et al.
patent: 5866578 (1999-02-01), Mylari et al.
patent: 6414149 (2002-07-01), Chu-Moyer et al.
patent: 6602875 (2003-08-01), Chu-Moyer et al.
patent: 3905364 (1990-08-01), None
patent: 0384370 (1990-08-01), None
patent: 470616 (1992-02-01), None
patent: 0470616 (1992-02-01), None
patent: 0794355 (2002-06-01), None
patent: WO9407867 (1994-04-01), None
Chemical abstract DN 116:194353, also cited as E 470616.*
Ao, S., et al., Metabolism, 40, pp. 77-87, 1991.
Cameron, NE and Cotter, M.A., Diabetic Medicine, 8, Supp. 1, 35A-36A, 1991.
Geisen, K. et al., Arzneim Forsch, vol. 44, No. 9, 1994, pp. 1032-1043.
Schmidt, R.E., et al., Jrnl. Neur. Expt, Neur. 57 / 12, pp. 1175-1189.
Brown, D. J. The Pyrimidines, 1962.
Chu-Moyer Margaret Y.
Murry Jerry A.
Mylari Banavara L.
Zembrowski William J.
Benson Gregg C.
Patel Sudhaker B.
Pfizer Inc
Raymond Richard L.
Richardson Peter C.
LandOfFree
Sorbitol dehydrogenase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sorbitol dehydrogenase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sorbitol dehydrogenase inhibitors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3449628