Sorbitan esters as skin permeation enhancers

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...

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424447, 424448, A61F 1300

Patent

active

051223830

ABSTRACT:
Skin permeation enhancer compositions are provided which increase the permeability of skin to transdermally administered pharmacologically active agents. The compositions contain a sorbitan ester in addition to the selected pharmacologically active agent, and may also contain a C.sub.1 -C.sub.4 aliphatic alcohol. Methods and transdermal drug delivery systems for using the compositions are also provided.

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T. Ogiso et al., J. Pharmacobio-Dyn., 9:517-525.
T. Ogiso et al., J. Pharm. Sci., 78(4):319-323 (1989).
W. W. Shen et al., J. Pharm. Sci., 65(12):1780-1783 (1986).

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