Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1994-12-23
1996-08-20
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
435 694, A61K 3827, C07K 1461
Patent
active
055480683
ABSTRACT:
The present invention relates to somatotropin analogues with amino acid changes in the alpha-helix 1 regions of said somatotropins, alone or in combination with mutations in the alpha-helix 3 and/or alpha-helix 2 regions, plus combinations with other changes to the native amino acid sequence of somatotropins. The resulting analogues are stable for formulation in sustained release formulations, while maintaining biological activity. Further, methods for conducting site-directed mutagenesis on DNA encoding proteins and/or polypeptide also are provided.
REFERENCES:
Gooley et al. 1988 Biochemistry 27: 4032.
Brems et al 1987 Biochemistry 26: 7774.
Abdel-Meguid et al 1987 PNAS 84: 6434.
Chem et al. 1990 PNAS 87: 5061.
Chaleff Deborah T.
Fischer Meir
Lebens Michael R.
American Cyanamid Company
Bio-Technology General Corp.
Carlson K. Cochrane
Draper Garnette D.
White John P.
LandOfFree
Somatotropins with alterations in the alpha-helix 1 region, and does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Somatotropins with alterations in the alpha-helix 1 region, and , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Somatotropins with alterations in the alpha-helix 1 region, and will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2331520