Somatotropin variants and their use

Details Somatotropin variants and their use Somatotropin variants and their use

1988-08-29

1992-02-18

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 21, 530324, 530350, A61K 3702, A61K 3736, C07K 1300

Patent

active

050894730

ABSTRACT:
Variant forms of mammalian somatotropins, particularly bovine and porcine somatotropin, in which the asparagine located between positions 95-101 has been replaced by glutamine exhibit enhanced stability at high pH and at elevated temperatures while retaining bioactivity equivalent to the corresponding unmutated somatotropins, and are useful in the treatment of animals to enhance growth and/or milk production.

REFERENCES:
Proc. Nat'l. Acad. Sci., U.S.A., 84:6434-37, (1987), S. S. Abdel-Megui et al., "Three-Dimensional Structure of a Genetically Engineered Variant of Porcine Growth Hormone".

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