Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1994-12-29
1997-09-02
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
435 694, C07K 1461, A61K 3827, C12P 2106
Patent
active
056633050
ABSTRACT:
The present invention provides analogs of animal somatotropins particularly with changes in the amino acids between residue 96 to 133 which are changed to reduce hydrophobicity or helical stability.
REFERENCES:
N.E. Down, et al., Can. J. Fish. Aquat. Sci, vol. 46, (1989) pp. 178-83, "A Potent Analog of Recombinant Bovine Somatotropin Accelerates Growth in Juvenile Coho Salmon (Oncorhynchus kisutch)".
Levitt et al. Biochemistry 17(20): 4277 1978.
Brems et al Biochemistry 26:7774 1987.
Brems et al. PNAS 85:3367 1988.
Watahiki et al 1989 J Biol. Chem. 264:312-316.
Brems David N.
Havel Henry A.
Lehrman Sherwood Russ
Plaisted Scott M.
Tuls Jody L.
Carlson K. Cochrane
Darnley, Jr. James D.
Koivuniemi Paul J.
Steele Gregory W.
The Upjohn Company
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