Somatostatin receptors

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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Other Related Categories

435 72, 435 691, 436501, C12N 510, G01N 3353

Type

Patent

Status

active

Patent number

057232997

Description

ABSTRACT:
The invention relates generally to compositions of and methods for obtaining somatostatin receptors. The invention relates as well to the DNA sequences encoding somatostatin receptors, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant somatostatin receptor polypeptides. By way of example, the invention discloses the cloning and functional expression of at least three different somatostatin receptors, SSTR1, SSTR2 and SSTR3 from two different mammalian sources. The invention includes as well, methods for using the isolated, recombinant receptor polypeptides in assays designed to select and improve substances capable of interacting with somatostatin receptor polypeptides for use in diagnostic, drug design and therapeutic applications.

REFERENCES:
He et al, P.N.A.S. 86: 1480-1484, Mar. 1989.
Chou et al.,J. Clin. Invest. 79:175-178, Jan. 1987.

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