Somatostatin analogs having a substituted tryptophyl residue in

Details Somatostatin analogs having a substituted tryptophyl residue in Somatostatin analogs having a substituted tryptophyl residue in

1979-04-09

1980-09-23

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

2601125S, 424177, C08L 3700, C07C10352, A61K 3700

Patent

active

042241995

ABSTRACT:
Tetradecapeptides of the formula ##STR1## in which A represents L, D or DL 5- or 6- fluoro-, bromo-,chloro- or iodotryptophyl, or a therapeutically acceptable acid addition salt thereof, their preparation and intermediates for their preparation are disclosed. The tetradecapeptides are useful for inhibiting the release of growth hormone. Compositions and methods for their use also are disclosed.

REFERENCES:
J. Rivier, et al., Biochem. Biophys. Res. Commun., 65, 746 (1975).
D. H. Coy, et al., Endocrinology 98, 305A (1976).
D. H. Coy, et al., Biochemistry 13, 3550 (1974).
Meyers, et al., Biochemistry, 2326-2330, 1978.

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