Somatostatin analogs and intermediates thereto

Details Somatostatin analogs and intermediates thereto Somatostatin analogs and intermediates thereto

1976-04-29

1977-12-06

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

040616266

ABSTRACT:
The tetradecapeptides ##STR1## in which Y is Gly or D-Ala are described along with corresponding non-toxic pharmaceutically-acceptable acid addition salts as well as intermediates useful in the synthesis of the tetradecapeptides. The tetradecapeptide in which Y is Gly as well as its pharmaceutically acceptable acid addition salts exhibit as their principal activity the in vivo inhibition of the release of gastric acid. The tetradecapeptide in which Y is D-Ala as well as its pharmaceutically acceptable acid addition salts exhibit as their principal activity the in vivo stimulation of the release of growth hormone.

REFERENCES:
patent: 3842066 (1974-10-01), McKinley et al.
patent: 3842067 (1974-10-01), Sarantakis
patent: 3882098 (1975-05-01), Sarantakis
patent: 3896105 (1975-07-01), Chai et al.
patent: 3904594 (1975-09-01), Guillemin et al.
patent: 3917581 (1975-11-01), Immer et al.
patent: 3931140 (1976-01-01), Sarantakis
L. Ferland, et al.; Molecular and Cellular Endocrinology 4, 79-86 (1976).
Biochem. and Biophysical Research Comm. 65, (1975), 746-750.

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