Somatostatin analogs

Details Somatostatin analogs Somatostatin analogs

1977-09-06

1978-08-01

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

041042670

ABSTRACT:
Somatostatin analogs which contain L-His.sup.4 -L-His.sup.5 amino acid residues in place of the normally present L-Lys.sup.4 -L-Asn.sup.5 residues are disclosed. Other modifications of somatostatin are also disclosed.
These compounds inhibit the release of pituitary growth hormone, glucagon, and insulin.

REFERENCES:
Rivier et al., B.B.R.C. 65, 746 (1975).
Rivier et al., S. Med. Chem. 18, 123 (1975).

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