Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1976-06-14
1979-07-17
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125S, A61K 3700, C07C10352
Patent
active
041615212
ABSTRACT:
Somatostatin analogs having the structural formula: ##STR1## are prepared by controlled stepwise procedures starting with individual amino acid components. These peptides have the property of lowering blood glucose, inhibiting gastric secretion, inhibiting growth hormone release and inhibiting glucagon release in humans and animals.
REFERENCES:
patent: 3842066 (1974-10-01), McKinley et al.
patent: 3904594 (1975-09-01), Guillemin et al.
patent: 3988304 (1976-10-01), Garsky
J. Med. Chem. 18, 123 (1975).
Endocrinology 98, 336 (1976).
Biochem. Biophys. Res. Commun. 65, 746 (1975).
Coll. Czech. Chem. Commun. 32, 1229 (1967).
Experientia 20, 570 (1964).
J.A.C.S. 98, 2367 (1967).
Hirschmann Ralph F.
Holly Frederick W.
Nutt Ruth F.
Paleveda William J.
Strachan Robert G.
Merck & Co. , Inc.
Patton Walter
Phillips Delbert R.
Westlake, Jr. Harry E.
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