Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1977-12-01
1979-02-20
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125S, A61K 3700, C07C10352
Patent
active
041407679
ABSTRACT:
Bicyclic somatostatin analogs and pharmaceutically acceptable non-toxic acid addition salts thereof are prepared by the solid phase method. These analogs have the property of inhibiting the release of growth hormone without affecting the level of gastric secretions or without affecting the level of gastric secretions, insulin and glucagon in humans and animals. The compounds are particularly useful in the treatment of acromegaly and diabetic retinopathy. Due to the bicyclic structure, these analogs are resistant to enzymatic metabolism and have a longer duration of activity than somatostatin.
REFERENCES:
patent: 3997517 (1976-12-01), Sarantakis
Sarantakis et al., Biochem. Biophys. Res. Comm., 75, 143-148 (1977).
Merck & Co. , Inc.
Patton Walter
Phillips Delbert R.
Westlake, Jr. Harry E.
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