Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-04-01
2000-02-15
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142355, 514255, 514318, 514322, 544129, 544364, 546187, 546194, 546199, A61K 31445, C07D 4010, C07D40112
Patent
active
06025372&
ABSTRACT:
Somatostatin agonist compounds of formula I are disclosed: ##STR1## including pharmaceutically acceptable salts and hydrates thereof These compounds are useful in the treatment of diabetes, cancer, acromegaly, restenosis, depression, irritable bowel syndrome and pain. The compounds are potent with high selectivity toward the receptor subtype 2.
Pharmaceutical compositions and methods of treatment are also included.
REFERENCES:
patent: 5710155 (1998-01-01), Schnorrenberg et al.
patent: 5869489 (1999-02-01), Shah et al.
Rudolf, K., et al., Chemical Abstracts, vol. 128, p. 604, 1998.
Bhattacharjee "A quantum chemical study of some model anti-inflammatory compounds" CA 117:39826, 1990.
Chapman Kevin
Guo Liangqin
Pasternak Alexander
Patchett Arthur A.
Tata James R.
Billups Richard C.
Chang Ceila
McGinnis James L.
Merck & Co. , Inc.
Rose David L.
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