Somatic mutations in neurofibromatosis type 1 gene in human tumo

Details Somatic mutations in neurofibromatosis type 1 gene in human tumo Somatic mutations in neurofibromatosis type 1 gene in human tumo

1995-03-28

1997-02-25

Sisson, Bradley L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435 912, 435 9151, 536 231, 536 235, 536 243, 536 2431, 536 2433, 536 253, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2104, C12N 1500

Patent

active

056057997

ABSTRACT:
The present invention is directed to somatic mutations of the NF1 gene which are found in human tumors. In addition, the present invention is directed to methods of screening humans to determine those having somatic mutations in the NF1 gene in tumors. Finally, the invention is directed to a method of treating a human having a tumor with a somatic mutation in the NF1 gene by restoring natural regulation of ras proteins.

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