Somatic gene therapy to cells associated with fluid spaces

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 691, 4351723, 4353201, 435325, A61K 31735, C12P 2102, C12N 1564, C12N 516

Patent

active

057705801

ABSTRACT:
This invention relates to somatic gene therapy to cells associated with fluid spaces, such as follicles of the thyroid, the synovium of the joint, the vitreous of the eye and the inner or middle ear. Formulated DNA expression vectors are introduced with or without formulation elements into fluid spaces under conditions in which cells associated with the fluid space can incorporate the formulated DNA expression vector. Formulated DNA expression-mediated gene therapy allows treatment of diseases involving cells associated with fluid spaces.

REFERENCES:
patent: 4751180 (1988-06-01), Cousens et al.
patent: 5166320 (1992-11-01), Wu et al.
patent: 5175146 (1992-12-01), Basava et al.
patent: 5194654 (1993-03-01), Hostetler et al.
patent: 5223263 (1993-06-01), Hostetler et al.
patent: 5580859 (1996-12-01), Felgner et al.
patent: 5589466 (1996-12-01), Felgner et al.
Marshall Gene therapy's growing pains Science vol. 269 1050-1055, 1995.
Orkin et al. Report and recommendations of the panel to assess the NIH investment in research on gene therapy, pp. 1-40, 1995.
Anderson, "Prospects for Human Gene Therapy," 226 Science 401, 1984.
Anderson, "Human Gene Therapy," 256 Science 808, 1992.
Ascadi et al., "Human Dystrophin Expression in mdx Mice After Intramuscular Injection of DNA Constructs," 352 Nature 815, 1991.
Asher et al., "Murine Tumor Cells Transduced with the Gene for Tumor Necrosis Factor-.alpha.," 146 J. Immunol. 3227, 1991.
Bandara et al., "Gene Transfer to Synoviocytes: Prospects for Gene Treatment of Arthritis," 11(3) DNA and Cell Biology 227, 1992.
Bell et al., "Reconstruction of a Thyroid Gland Equivalent From Cells and Matrix Materials," 232 J. Exp. Zoology 277, 1984.
Bonnerot "A .beta.-Galactosidase Hybrid Protein Targeted to Nuclei as a Marker for Developmental Studies," 84 PNAS 6795, 1987.
Cornetta et al., "Safety Issues Related to Retroviral-Mediated Gene Transfer in Humans," 2 Hum. Gen. Ther. 5, 1991.
Culver et al., "Lymphocyte Gene Therapy," 2 Hum. Gen. Ther. 107, 1991.
Curiel et al., "Adenovirus Enhancement of Transferrin-polylysine-mediated Gene Delivery," 88 PNAS 8850, 1991.
Dingle et al., "A Cartilage Catabolic Factor From Synovium," 184 Biochem. J. 177, 1979.
Felgner et al., "Lipofection: A Highly Efficient, Lipid-Mediated DNA-Transfection Procedure," 84 PNAS 7413, 1987.
Firestein et al., "Quantitative Analysis of Cytokine Gene Expression in Rheumatoid Arthritis," 144 J. Immunol. 3347, 1990.
Friedmann, "Progress Toward Human Gene Therapy," 244 Science 1275, 1989.
Hubbard et al., "Effect of Purified Human Interleukin-1 on Cartilage Degradation," 6 J. Orthop. Res. 180, 1988.
Jaffe et al., "Adenovirus-Mediated In Vivo Gene Transfer and Expression in Normal Rat Liver," 1 Nature Genetics 372, 1992.
Jiao et al., "Direct Gene Transfer into Nonhuman Primate Myofibers In Vivo," 3 Hum. Gen. Ther. 21, 1992.
Ledley, "Somatic Gene Therapy in Gastroenterology: Approaches and Applications," 14 J. Pediatr. Gast. Nutr. 328, 1992.
Ledley, "Hepatic Gene Therapy: Present and Future," 18 Hepatology 1263, 1993.
Ledley, "Are Contemporary Methods for Somatic Gene Therapy Suitable for Clinical Applications?" 16 Clin. Invest. Med. 78, 1993.
Ledley, "Human Gene Therapy," Jacobson and Jolly vol. Eds., Biotechnology, vol 7b Gene Technology, Munich: VCH Verlagsgesellschaft, 401-457, 1989.
Lem et al., "Retinal Degeneration is Rescued in Transgenic rd Mice by Expression of the cGMP Phosphodiesterase .beta. Subunit," 89 Proc. Natl. Acad. Sci. USA 4422, 1992.
Levick, "Permeability of Rheumatoid and Normal Human Synovium to Specific Plasma Proteins," 24 Arthritis Rheum. 1550, 1981.
Lafferty et al., "Mechanism of Thyroid Allograft Rejection," 54 Aust. J. Exp. Biol. Med. Sci. 573,1976.
Lin et al., "Expression of Recombinant Genes in Myocardium In Vivo After Direct Injection of DNA," 82 Circulation 2217, 1990.
MacGregor, "Histochemical Staining of Clonal Mammalian Cell Lines Expressing E. Coli .beta. Galactosidase Indicates Heterogenous Expression of the Bacterial Gene," 13 Somat. Cell. Mol. Genet. 253, 1987.
McDonnell, et al., "Nuclear Hormone Receptors as Targets for New Drug discovery," BioTechniques 11:1256-1261 (1993).
Miller and Rosman, "Improved Retroviral Vectors for Gene Transfer and Expression," 7(9) BioTechniques 980, 1989.
Miller, "Human Gene Therapy Comes of Age," 357 Nature 455, 1992.
Miossec et al., "Interleukin-1 Lymphocyte Chemotactic Activity in Rheumatoid Arthritis Synovial Fluid," 29 Arthritis Rheum. 461, 1986.
Moolten and Cupples, "A Model for Predicting the Risk of Cancer Consequent to Retroviral Gene Therapy," 3 Hum. Gen. Ther. 479, 1992.
Morgan et al., "Applications of the Polymerase Chain Reaction in Retroviral-Mediated Gene Transfer and the Analysis of Gene-Marked Human TIL Cells," 1 Hum. Gen. Ther. 135, 1990.
Morgan et al., "Expression of an Exogenous Growth Hormone Gene by Transplantable Human Epidermal Cells," 237 Science 1476, 1987.
Mulligan, "The Basic Science of Gene Therapy," 260 Science 926, 1993.
Nabel et al., "Recombinant Gene Expression In Vivo Within Endothelial Cells of the Arterial Wall," 244 Science 1342, 1989.
Nicolau and Cudd, "Liposomes as Carriers of DNA," 6 Crit. Rev. Ther. Drug Carrier Syst. 239, 1989.
O'Malley, Jr. and Ledley, "Somatic Gene Therapy in Otolaryngology-Head and Neck Surgery," 119 Arch. Otolaryngol. Head Neck Surg. 1191, 1993.
Olsson et al., "Transgenic Mice with a Rhodopsin Mutation (Pro23His): A Mouse Model of Autosomal Dominant Retinitis Pigmentosa," 9 Neuron 815, 1992.
Palmer et al., "Genetically Modified Skin Fibroblasts Persist Long After Transplantation but Gradually Inactivated Introduced Genes," 88 Proc. Natl. Acad. Sci. USA 1330, 1991.
Peter et al., "Comparison of FRTL-5 Cell Growth In Vitro with That of Xenotransplanted Cells and the Thyroid of the Recipient Mouse," 128 Endocrin. 211, 1991.
Pettipher et al., "Interleukin 1 Induces Leukocyte Infiltration and Cartilage Proteoglycan Degradation in the Synovial Joint," 83 Proc. Natl. Acad. Sci. USA 8749, 1986.
Quantin et al., "Adenovirus as an Expression Vector in Muscle Cells In Vivo," 89 Proc. Natl. Acad. Sci. USA 2581, 1992.
Rosenberg et al., "Gene Transfer Into Humans--Immunotherapy of Patients with Advanced Melanoma, Using Tumor-Infiltrating Lymphocytes Modified by Retroviral Gene Transduction," 323 New Engl. J. Med. 570, 1990.
Rosenberg, "Gene Therapy for Cancer," 268 J. Am. Med. Assoc. 2416, 1992.
Rosenfeld et al., "A Null Mutation in the Rhodopsin Gene Causes Rod Photoreceptor Dysfunction and Autosomal Recessive Retinitis Pigmentosa," 1 Nature Genet. 209, 1992.
Rosenfeld et al., "In Vivo Transfer of the Human Cystic Fibrosis Transmembrane Conductance Regulator Gene to the Airway Epithelium," 68 Cell 143, 1992.
Scharfmann et al., "Long-term In Vivo Expression of Retrovirus-mediated Gene Transfer in Mouse Fibroblast Implants," 88 Proc. Natl. Acad. Sci. USA 4626, 1991.
Sikes, et al., "In Vivo and Ex Situ Gene Transfer to the Thyroid for Somatic Gene Therapy in Animal Models," Am. J. Hum. Gen. 51:A227, Abstract 894 (1992).
Sikes, et al., "In Vivo Gene Transfer into Rabbit Thyroid b Direct DNA Injection: A Novel Strategy for Gene Therapy," J. Cell. Biochem. 17E:208, Abstract S 315 (1993).
Skolnik et al., "Autotransplantation in Lingual Ectopia of Thyroid Gland," 78 Arch. Otolaryngol. 187, 1963.
Swan et al., "Thyroid Autograft," 94 Arch. Surg. 817, 1967.
Legendre and Szoka, Jr., "Cyclic Amphipathic Peptide-DNA Complexes Mediate High-Efficiency Transfection of Adherent Mammalian Cells," 90 Proc. Natl. Acad. Sci. USA 893, 1993.
Chu et al., "Efficiency of Cytoplasmic Delivery of pH-Sensitive Liposomes to Cells in Culture," 7 Pharm. Res. 824, 1990.
Haensler and Szoka, Jr., "Synthesis and Characterization of a Trigalactosylated Bisacridine Compound to Target DNA To Hepatocytes," 4 Bioconjug. Chem. 85, 1993.
Legendre and Szoka, Jr., "Delivery of Plasmid DNA into Mammalian Cell Lines Using pH-Sensitive Liposomes: Comparison with Cationic Liposomes," 9 Pharm. Res. 1235, 1992.
Talmage et al., "Activation of Transplant Immunity: Effect of Donor Leukocytes on Thyroid Allograft Rejection," 191

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Somatic gene therapy to cells associated with fluid spaces does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Somatic gene therapy to cells associated with fluid spaces, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Somatic gene therapy to cells associated with fluid spaces will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1394855

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.