Solvent system to be enclosed in capsules

Details Solvent system to be enclosed in capsules Solvent system to be enclosed in capsules

1995-03-08

1999-06-15

Harrison, Robert H.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424452, 514962, A61K 908, A61K 948

Patent

active

059120118

ABSTRACT:
To increase the solubility of acidic medicines a high concentration solvent system to be encapsulated comprises
a) 10-80% by weight acidic medicine,
b) 0.1-1.0 mole hydroxide ions for one mole equivalent of said medicine, and
c) 1-20% by weight water.
included in polyoxyethylene sorbitan fatty acid ester as the solvent.

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Patel et al., 1992, Drug Development and Industrial Pharmacy 18(1): 1-19 "Factors Affecting the Chemical Stability of Carboxylic Acid Drugs in Enhanced Solubility System (ESS) Softgel Formulations Based on Polyethylene Glycol (PEG)."

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