Solvent system for chronic vascular infusion of hydrophobic drug

Details Solvent system for chronic vascular infusion of hydrophobic drug Solvent system for chronic vascular infusion of hydrophobic drug

1988-04-06

1990-07-24

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514724, A61K 3700, A61K 31045

Patent

active

049435604

ABSTRACT:
The present invention provides a liquid infusate for the chronic vascular infusion of a hydrophobic biologically-active compound, such as cyclosporin, comprising a solution of a therapeutically-effective amount of the biologically-active compound in a mixture of about 10-80% glycerol and about 90-20% ethanol, by volume.

REFERENCES:
patent: 3731681 (1973-05-01), Blackshear
patent: 4108985 (1978-08-01), Ruegger et al.
patent: 4439181 (1984-03-01), Blackshear et al.
patent: 4998823 (1989-01-01), Witzel
The Merck Index, 10th Ed.(1983), p. 396, No. 2748.
Wigness et al., Chem. Abst. 105(9):85142g.
B. D. Wigness et al., Trans. Am. Soc. Artif. Inter. Organs, XXXI, 136-139, (1985).
Brange et al., Properties of Insulin in Solution, in Artificial Systems for Insulin Delivery (P. Brunetti 1983), at pp. 83-84. Lougheed et al., Diabetologia, 19, 1-9 (1980).
H. Buchwald et al., Implantable Infusion Pumps, Year Book medical Publishers, Inc., 177-221 at 185 (1984).

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