Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1991-05-03
1993-10-19
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 436150, 436173, 436517, 436519, 436526, 436806, G01N 3353
Patent
active
052544605
ABSTRACT:
A new ligand binding assay is based upon measurements of relaxation rates of the solvent, which are obtained with a magnetic resonance (MR) spectrometer. It is termed a solvent mediated relaxation assay system (SMRAS). SMRAS is based on the observation that the enhancement of proton relaxation rates produced by a magnetic material can be modulated by the binding of various analytes to a magnetic material. Hence the relaxation rate of the solvent can be interpreted to give information on the concentration of an analyte.
REFERENCES:
patent: 3453288 (1969-07-01), McConnell
patent: 3933997 (1976-01-01), Hersh et al.
patent: 4141687 (1979-02-01), Forrest et al.
patent: 4219335 (1980-08-01), Ebersole
patent: 4386054 (1983-05-01), Takenchi
patent: 4452773 (1984-06-01), Molday
patent: 4554088 (1985-10-01), Whitehead et al.
patent: 4661408 (1987-04-01), Lau et al.
patent: 4795698 (1989-01-01), Owen et al.
Thulborn et al (1982) Biochem Biophys. Acta 714 pp. 265-270 ref #AO.
Khaw et al. (1980) Science 209 pp. 295-297.
Krick, L. J. (1985) "Ligand Binder Assays, Labels and Analytic Strategies" Marcel Dekker, New York pp. 233-239.
Meares et al. (1984) Acc. Chem. Res. 17 pp. 202-209.
Meares et al. (1984) Anal. Biochem. 142 pp. 68-78.
Ogan et al. (1987) Invest. Radiol. 22 pp. 665-671.
Willard, H. H. et al. "Instrumental Methods of Analysis" Van Nostrand, Princeton, N.J., 1965, pp. 160-195.
Wolf et al. in Magnetic Resonance Annual 1985, H. Y. Kressel, ed., Raven Press, N.Y., pp. 231-266.
Groman Ernest V.
Josephson Lee
Menz Edward T.
Advanced Magnetics Inc.
Nucker Christine M.
Stucker Jeffrey
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