Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
2005-08-24
2008-07-01
Kifle, Bruck (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
active
07393952
ABSTRACT:
An improved process for coating implantable medical devices utilizes a number of techniques for improving the stability of therapeutic agents contained within the coating. The stability of the therapeutic agents may be improved by creating substantially solvent-free, amorphous forms of the therapeutic agents.
REFERENCES:
patent: 3929992 (1975-12-01), Seghal et al.
patent: 94/09010 (1994-04-01), None
patent: 97/03654 (1997-02-01), None
patent: 01/87893 (2001-11-01), None
patent: 02/057228 (2002-07-01), None
patent: 2004/028582 (2004-04-01), None
patent: 2005/011688 (2005-02-01), None
patent: 2005/023254 (2005-03-01), None
Berk, B. C. et al., “Heparins and Glucocorticoids Inhibit Restenosis,” J. Am. Coll. Cardiol., 1991, 17, 111B-117B.
Campbell, G. R. and Campbell, J. H., “Phenotypic Modulation of Smooth Muscle Cells in Primary Culture,” In:Vascular Smooth Muscle in Culture, vol. 1, Ch. 4, Boca Raton, FL: CRC, 1987, pp. 39-55.
Campbell, G. R., et al., “Smooth muscle phenotypic changes in arterial wall homeostasis: implications for the pathogenesis of atherosclerosis,” Exp. Mol. Pathol., Apr. 1985, 42(2), 139-162.
Chang, M. W. et al., “Adenovirus-mediated Over-expression of the Cyclin/Cyclin-dependent,” J. Clin. Invest., 1995, 96, 2260-2268.
Clowes, A. W. et al., “Kinetics of cellular proliferation after arterial injury. IV. Heparin inhibits rat smooth muscle mitogenesis and migration,” Circ. Res., 1986, 58(6), 839-845.
Clowes, A. W. et al., “Kinetics of cellular proliferation after arterial injury. II. Inhibition of smooth muscle growth by heparin,” Lab. Invest., 1985, 52(6), 611-616.
Clowes, A. W. et al., “Significance of quiescent smooth muscle migration in the injured rat carotid artery,” Circ Res. 1985, 56(1), 139-145.
Clowes, A. W., “Suppression by heparin of smooth muscle cell proliferation in injured arteries,” Nature, 1977, 265(5595), 625-626.
Colburn, M. D. et al., “Dose responsive suppression of myointimal hyperplasia by dexamethasone,” J. Vasc. Surg., 1992, 15, 510-518.
Currier, J. W. et al., “Colchicine Inhibits Restenosis After Iliac Angioplasty in the Atherosclerotic Rabbit,” Circ., 1989, 80(4), 11-66 (Abstract No. 0263).
Edelman, E. R. et al., “Pathobiologic responses to stenting,” Am J. Cardiol. 1998, 81(7A), 4E-6E.
Farb, A. et al., “Vascular smooth muscle cell cytotoxicity and sustained inhibition of neointimal formation by fibroblast growth factor 2-saporin fusion protein,” Circ. Res., 1997, 80, 542-550.
Ferns, G. A. A. et al., “Inhibition of Neointimal Smooth Muscle Accumulation After Angioplasty by an Antibody to PDGF,” Science, 1991, 253, 1129-1132.
Fischman, D. L. et al., “A Randomized Comparison of Coronary-Stent Placement and Balloon Angioplasty in the Treatment of Coronary Artery Disease,” N. Eng. J. Med., Aug. 25, 1994, 331(8), 496-501.
Franklin, S. M. et al., “Pharmacologic prevention of restenosis after coronary angioplasty: review of the randomized clinical trials,” Coron Artery Dis. Mar. 1993, 4(3), 232-242.
Fukuyama, J. et al., “Tranilast suppresses the vascular intimal hyperplasia after balloon injury in rabbits fed on a high-cholesterol diet,” Eur. J. Pharmacol., 1996, 318, 327-332.
Guyton, J. R. et al., “Inhibition of rat arterial smooth muscle cell proliferation by heparin. In vivo studies with anticoagulant and nonanticoagulant heparin,” Circ. Res., 1980, 46, 625-634.
Hancock, B. C. et al., “The Relationship Between the Glass Transition Temperature and the Water Content of Amorphous Pharmaceutical Solids,”Pharmaceutical Research, 1994, 11(4), 471-477, XP008031768.
Hanson, S. R. et al., “Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone,” Proc. Natl. Acad. Sci. USA, 1988, 85, 3184-3188.
Jonasson, J. et al., “Cyclosporin A inhibits smooth muscle proliferation in the vascular response to injury,” Proc. Natl., Acad. Sci., 1988, 85, 2303-2306.
Lang, R. J. et al., “Effects of 2,3-butanedione monoxime on whole-cell Ca2+ channel currents in single cells of the guinea-pig taenia caeci,” J Physiol. Feb. 1991, 433, 1-24.
Lang, R. J. et al., “Effects of okadaic acid and ATP gamma S on cell length and Ca(2+)-channel currents recorded in single smooth muscle cells of the guinea-pig taenia caeci.,”, Br. J. Pharmacol., Oct. 1991, 104(2), 331-336.
Liu, M. W. et al., “Trapidil in Preventing Restenosis After Balloon Angioplasty in the Atherosclerotic Rabbit,” Circ., 1990, 81, 1089-1093.
Lundergan, C. F. et al., “Peptide Inhibition of Myointirnal Proliferation by Angiopeptin, a Somatostatin Analogue,” Am. J. Cardiol., 1991, 17(Suppl. B), 132B-136B.
Majesky, M. W. et al., “Heparin regulates smooth muscle S phase entry in the injured rat carotid artery,” Circ. Res., 1987, 61, 296-300.
Mak, K-H. et al., “Clinical trials to prevent restenosis after percutaneous coronary revascularization,” Ann N Y Acad Sci., Apr. 15, 1997, 811, 255-84; discussion 284-8. Review.
Marx, S. O. et al., “Rapamycin-FKBP Inhibits Cell Cycle Regulators of Proliferation in Vascular Smooth Muscle Cells,” Circ. Res., 1995, 76, 412-417.
Nemecek, G. M. et al., “Terbinafine Inhibits the Mitogenic Response to Platelet-Derived Growth Factor in Vitro and Neoinimal Proliferation in Vivo,” J. Pharmacol. Exp. Thera., 1989, 248, 1167-1174.
Okada, T. et al., “Localized Release of Perivascular Heparin Inhibits Intimal Proliferation after Endothelial Injury without Systemic Anticoagulation,” Neurosurgery, 1989, 25, 92-98.
Popma, J. J. et al , “Atherectomy of right coronary ostial stenoses: initial and long-term results, technical features and histologic findings,” Am J Cardiol., Feb. 15, 1991; 67(5), 431-433.
Popma, J. J. et al., “Adjuncts to thrombolysis for myocardial reperfusion,” Ann Intern Med., Jul. 1, 1991, 115(1), 34-44.
Popma, J. J. et al., “Clinical trials of restenosis after coronary angioplasty,” Circulation, Sep. 1991, 84(3), 1426-1436.
Popma, J. J. et al., “Clinical, angiographic and procedural correlates of quantitative coronary dimensions after directional coronary atherectomy,” J Am Coll Cardiol., Nov. 1, 1991, 18(5), 1183-1189.
Powell, J. S. et al., “Inhibitors of Angiotensin-Converting Enzyme Prevent Myointimal Proliferation After Vascular Injury,” Science, 1989, 245, 186-188.
Serruys, P. W. et al., “A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease,” N Engl J Med, Aug. 25, 1994; 331(8), 489-495.
Serruys, P. W. et al., “Evaluation of ketanserin in the prevention of restenosis after percutaneous transluminal coronary angioplasty. A multicenter randomized double-blind placebo-controlled trial,” Circulation, Oct. 1993; 88(4 Pt 1), 1588-1601.
Serruys, P. W. et al., “Heparin-coated Palmaz-Schatz stents in human coronary arteries. Early outcome of the Benestent-II Pilot Study,” Circulation, Feb. 1, 1996; 93(3), 412-422.
Serruys, P. W. et al., “Randomized trials of coronary stenting,” J Interv Cardiol, Aug. 1994; 7(4), 331.
Serruys, P. W. et al., “Restenosis revisited: insights provided by quantitative coronary angiography,” Am Heart J, Nov. 1993; 126(5), 1243-1267.
Serruys, P. W. et al., “The bailout stent. Is a friend in need always a friend indeed?” Circulation, Nov. 1993; 88(5 Pt 1), 2455-2457.
Simons, M. et al., “Antisense c-myboligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo,” Nature, 1992, 359, 67-70.
Snow, A. D. et al., “Heparin modulates the composition of the extracellular matrix domain surrounding arterial smooth muscle cells,&#x
Maryanoff Cynthia A.
Six Karel
Vandecruys Roger
Cordis Corporation
Evens Carl J.
Kifle Bruck
LandOfFree
Solvent free amorphous rapamycin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Solvent free amorphous rapamycin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Solvent free amorphous rapamycin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3968799