Solvent extraction process

Details Solvent extraction process Solvent extraction process

1991-09-13

1993-08-03

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424462, 424468, 424497, 264 433, 264 46, 530313, 521 56, A61K 916

Patent

active

052327078

ABSTRACT:
There is disclosed a process for the extraction of volatile solvents entrained in a polymer-based pharmaceutical composition designed for sustained release of drug over an extended period of time prepared in microcapsule form wherein the composition comprises at least one hormonally active water-soluble polypeptide in an effective amount greater than a conventional single dose and a biocompatible, bioerodable encapsulating polymer, which process comprises the steps of contacting the composition to a stream of dense gas, that is, pressurized gas and then removing the dense gas, and volatile solvents contained therein, extracted from the pharmaceutical composition.

REFERENCES:
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patent: 3843824 (1974-10-01), Roselius et al.
patent: 4234571 (1980-11-01), Nestor
patent: 4305838 (1981-12-01), Iwasaki
patent: 4389330 (1983-06-01), Tice
patent: 4675189 (1987-06-01), Kent
patent: 4777154 (1988-10-01), Torobin
patent: 4801577 (1989-01-01), Nestor et al.
patent: 4818542 (1989-04-01), DeLuca

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