Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1997-11-03
1999-03-30
Lee, Howard C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
424443, 514 54, 514 55, 514 56, 514 57, 514 58, 514 59, 514 60, 536123, 5361231, A61K 31715, A61F 1300
Patent
active
058889876
ABSTRACT:
The invention provides a method of preparing water-insoluble polysaccharide sponges, and sponges obtained by means of the method. The method comprises: (a) providing an aqueous solution of a soluble polysaccharide; (b) freezing the solution; (c) treating the frozen solution with a water-miscible organic solvent such as isopropanol to effect solvent exchange for the water in the frozen solution; and (d) drying the resulting polysaccharide material. The organic solvent contains a cross-linking agent such as calcium chloride to render the polysaccharide water-insoluble in the solvent-exchange step (c). The resulting materials are more conformable and less friable than freeze-dried polysaccharide sponges.
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Oungbho et al. Int. J. Pharm., vol. 156(2):229-237, (1997). Abstract Only.
Dumitriu et al. "Hydrogel Based Polysaccharides" From Polysaccharides in Medicinal Applications, ed. by Dumitriu, Severian; Marcel Dekker, pp. 125-171, (1996).
Dumitriu et al. "Hydrogels as Support For Drug Delivery Systems", Ibid. (pp. 705-717).
UK Search Report Application No. GB 9622394.6, 16 Jan. 1997, JJM-262.
Haynes Carla Anne
Lorimer Elaine
Farmer Andrew C.
Johnson & Johnson Medical Inc.
Lee Howard C.
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