Solvate and crystalline forms of carbamoyl-cyclohexane...

Details Solvate and crystalline forms of carbamoyl-cyclohexane... Solvate and crystalline forms of carbamoyl-cyclohexane...

2008-05-09

2010-11-09

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S393000

Reexamination Certificate

active

07829569

ABSTRACT:
The present invention relates to novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives and, more particularly, to novel solvate and crystalline forms of trans-1{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-3,3-dimethyl-urea hydrochloride. Processes for the preparation of these forms, compositions containing these forms, and methods of use thereof are also described.

REFERENCES:
patent: 6566550 (2003-05-01), Lowe, III
patent: 2006/0229297 (2006-10-01), Csongor et al.
patent: 2007/0259885 (2007-11-01), Bathe et al.
patent: WO 2006/034774 (2006-04-01), None
patent: WO 2007/033191 (2007-03-01), None
International Search Report for PCT/US2008/063181, mailed Aug. 15, 2008.
Written Opinion of the International Searching Authority for PCT/US2008/063181, mailed Aug. 15, 2008.
Gurevich et al., Mesolimbic Dopamine D3 Receptors and Use of Antipsychotics in Patients with Schizophrenia, A Postmortem Study, Archives of General Psychiatry, 54, 225-232, 1997. Abstract.

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