Solutions of oxaphosphorins having improved stability and proces

Details Solutions of oxaphosphorins having improved stability and proces Solutions of oxaphosphorins having improved stability and proces

1989-02-06

1990-08-28

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

A61K 3166

Patent

active

049525751

ABSTRACT:
Solutions comprising oxazaphosphorins having the general formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are radicals and at least two of said radicals are 2-chloroethyl and/or 2-mathanesulfonyloxyethyl and the remaining radical is selected from hydrogen, methyl and ethyl; and about 80% to about 100% (v/v) ethanol; wherein the oxazaphosphorin concentration is about 10% to about 70% (w/v); and a process for the preparation thereof.

REFERENCES:
Chemical Abstracts 105:12015h (1986) Abstracting Ziekenhuisfarmacie 1985 1(2) 57-58 (Weth).
Websters 3rd New International Dictionary, p. 74, 1988.
McGraw-Hill Dictionary of Scientific and Technical Terms 4th Edition, 1989, p. 81.
Chemical Abstracts, vol. 105, Ref.: 12015h.

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