Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Alkali or alkaline earth chloride
Patent
1994-08-18
1996-03-12
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Alkali or alkaline earth chloride
424679, 424681, 424682, 514 2, 514 23, 514 25, 514385, 514561, A61K 3314, A61K 3306, A61K 3800, A61K 3170, A61K 31415, A61K 3195
Patent
active
054984270
ABSTRACT:
Perfusion and preservation and/or reperfusion solutions for surgery and organ transplantation, including that of the heart, a feature of which solutions is the inclusion of at least one antioxidant compound, such as a trapping agent for free oxygen radicals, in particular glutathione in the reduced state or N-acetylcysteine, said solutions possessing a zero or greatly reduced partial pressure of oxygen which is maintained substantially at this value up to the time of use. The solution is preferably presented in flexible bags impermeable to oxygen.
REFERENCES:
patent: 4877810 (1989-10-01), Mickle
patent: 5095027 (1992-03-01), Goldberg
Astier et al; "Instability of Reduced Glutathione in Commercial Belzer Cold Storage Solution"; The Lancet, pp. 556-557; Sep. 2, 1989.
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Henley III Raymond
Pasteur Merieux Serums et Vaccines
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