Solution phase synthesis of oligonucleotides

Details Solution phase synthesis of oligonucleotides Solution phase synthesis of oligonucleotides

2006-03-28

2006-03-28

Wilson, James O. (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S025330, C536S025600, C536S026100, C536S023100, C536S022100, C514S04400A, C435S091100

Reexamination Certificate

active

07019127

ABSTRACT:
A process for the synthesis in solution phase of a phosphorothioate triester is provided. The process comprises the solution phase coupling of an H-phosphonate with an alcohol in the presence of a coupling agent to form an H-phosphonate diester. The H-phosphonate diester is oxidised in situ with a sulfur transfer agent to produce the phosphorothioate triester. Preferably, the H-phosphonate and alcohol are protected nucleosides or oligonucleotides. Oligonucleotide H-phosphonates which can be used in the formation of phosphorothioate triesters are also provided.

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