Solution phase biopolymer synthesis

Chemistry of hydrocarbon compounds – Special chemical considerations – Process including synthesis of nonhydrocarbon intermediate

Reexamination Certificate

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C585S932000, C585S933000, C585S934000, C585S935000, C585S400000, C585S800000

Reexamination Certificate

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07038103

ABSTRACT:
Multifunctional liquid phase carriers (LPCs) and methods of using LPCs for the preparation of biopolymers are provided. The LPCs are highly symmetrical compounds that possess more than two points of attachment for biopolymer synthesis. The LPCs have the formula Sp(X1)n, where Sp is a highly symmetrical moiety such that all X1groups are equivalent. X1is a functional group that is suitable for biopolymer synthesis, including OH, SH, NH2, COOH and the like. Biopolymers that may be produced using the methods provided include oligonucleotides, peptides, protein nucleic acids (PNAs) and oligosaccharides. Analogs of the biopolymers may also be prepared using the methods.

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