Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-10-30
2007-10-30
Padmanabhan, Sreeni (Department: 1617)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C435S001200
Reexamination Certificate
active
10088538
ABSTRACT:
The present invention is directed to preservation solutions for storing and perfusing a heart intended for transplantation to a patient requiring such implant. It was found that when cyclosporin is added to the preservation solution for to: (1) preserve the mitochondrial function which it does by maintaining adenosine triphosphate (“ATP”) levels, and (2) to block apoptosis and prevent programmed cell death. Therefore, the preservation of the mitochondrial function prevents necrosis while blocking prevents apoptosis.
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patent: 5925510 (1999-07-01), Schulsinger
Juado et al, 129CA:239628, 1998.
Massoudy et al, 126CA:338797, 1997.
Massoudy et al. “Cardioprotection by Cyclosporine A in Experimental Ischemia and Reperfusion” 1997, J. Mol. Cell. Cardiol., 29, 535-544.
Griffiths, E.J., Halestrap AP: Protection by cyclosporine A of ischemia/reperfusion-induced damage in isolated rat hearts,J Mol Cell Cardiol,(1993) 25:1461-1469.
Masters, T.N. et al.; “Extending myocardial viability during heart preservation with cyclosporine A.”; Journal of Heart and Lung Transplantation, vol. 19, No. 1, Jan. 2000, p. 41.
Alston & Bird LLP
Charlotte-Mecklenburg Hospital Authority
Padmanabhan Sreeni
Williams Leonard
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