Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2007-06-12
2007-06-12
Mertz, Prema (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S069100, C435S071100, C435S320100, C536S023500, C514S002600
Reexamination Certificate
active
10489553
ABSTRACT:
A novel, soluble protein similar to the known Toll-like receptor (TLR) family is disclosed. The present invention relates to these new soluble polypeptides, to nucleotide sequences encoding the polypeptides, to antibodies selectively binding to the polypeptide and to expression systems suitable for producing the polypeptide. The polypeptide is useful for modulating inflammatory reactions in mammals that include the actions of TLR.
REFERENCES:
patent: 5744145 (1998-04-01), Bertoli et al.
patent: 0 864 585 (1998-09-01), None
patent: WO 99/37772 (1999-07-01), None
patent: WO 0024776 (2000-05-01), None
patent: WO 0075358 (2000-12-01), None
James A. Wells, Sep. 18, 1990, Biochemistry, vol. 29, No. 37, pp. 8509-8517.
Iwaki et al. The Journal of Biological Chemistry, vol. 277, No. 27, pp. 24315-24320, Jul. 2002.
LeBouder et al, Journal of Immunology, 2003, vol. 171, pagers 6680-6689.
Flo et al. article entitled “Detection of Soluble TLR2 In Human Serum Samples by Elisa”NTNU, Institute of Cancer Research and Molecular Biology, Trondheim, Norway, 1 page.
Labéta et al. article entitled “Innate Recognition of Bacteria in Human Milk Is Mediated by a Milk-Derived Highly Expressed Pattern Recognition Receptor, Soluble CD14”J. Exp. Med., vol. 191, No. 10, May 15, 2000, pp. 1807-1812.
Filipp et al. article entitled “Soluble CD14 Enriched in Colostrum and Milk Induces B Cell Growth and Differentiation”PNAS, vol. 98, No. 2, Jan. 16, 2001, pp. 603-608.
Du et al. article entitled “Analysis of Tlr4-Medicated LPS Signal Transduction in Macrophages by Mutational Modification of the Receptor”Blood Cells, Molecules, and Diseases(1999 25(6) Nov. 15, 1999, pp. 328-338.
Xu et al. article entitled “Structural Basis for Signal Transduction by the Toll/Interleukin-1 Receptor Domains”Nature, vol. 408, Nov. 2, 2000, pp. 111-115.
Pruitt et al. article entitled “Increased Soluble Interleukin-1 Type II Receptor Concentrations in Postoperative Patients and in Patients With Sepsis Syndrome”Blood, vol. 87, No. 8, Apr. 15, 1996, pp. 3282-3288.
O'Neill et al. article entitled “The IL-I Receptor/Toll-Like Receptor Superfamily: Crucial Receptors for Inflammation and Host Defense”Trends, Immunology Today, May 2000, vol. 21, No. 5, pp. 206-209.
Mantovani et al. article entitled “Decoy Receptors: A Strategy to Regulate Inflammatory Cytokines and Chemokines”Trends in Immunology, vol. 22, No. 6, Jun. 2001, pp. 328-336.
Kolb article entitled “The Prospects of Modifying the Antimicrobial Properties of Milk”Biotechnology Advances, vol. 19, 2001, pp. 299-316.
Medzhitov R, Janeway CA Jr., article entitled “Innate Immunity: The Virtues of a Nonclonal System of Recognition”, CELL, vol. 91, pp. 295-298 (Oct. 31, 1997).
Imgenex, www.imgenex.com, website entitled: “Polyclonal Antibody to TLR2 (Toll-like Receptor 2)”, commercialized by Biocarta Europe GmbH, (Oct. 4, 2004).
Santa Cruz Biotechnology, Inc., www.scbt.com, website entitled: “TLR2 (N-17): sc-8689”, Apr. 2001.
Sambrook et al.,Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Press, Ch. 16-17, pp. 16.1-17.44 (1989).
D. Lipman et al., article entitled: “Basic Local Alignment Search Tool”, J. Mol. Biol., vol. 215, pp. 403-410 (1990), Altschul et al.
Altschul, S.F., et al., article entitled: “Gapped BLAST and PSI-BLAST: A New Generation of Protein Database Search Programs”, Nucleic Acids Res., vol. 25, pp. 3389-3402 (1997).
Smith, T.F. and Waterman, M.S., article entitled: “Pattern Recognition in Genetic Sequences by Mismatch Density”, Bull. Math. Biol., vol. 46, pp. 501-514 (1994), Sellers, Pecker.
Durieux, J.J., et al., article entitled: “The Two Soluble Forms of the Lipopolysaccharide Receptor, CD14: Characterization and Release by Normal Human Monocytes”, Eur. J. Immunol., vol. 24, pp. 2006-2012 (1994).
J. Coligan et al, “Electroblotting from Playacrylamide Gels”Current Protocols in Protein Science, J. Wiley & Sons, Ch. 10, Sec. 10.7 (1995).
J. Coligan et al, “In-Gel Digestion of Proteins for MALDI-MS Fingerprint Mapping”Current Protocols in Protein Science, J. Wiley & Sons, Ch. 16, Suppl. 14, Sec. 4 (1998), Jimencz et al.
Frey E.A., et al., article entitled: “Soluble CD14 Participates in the Response of Cells to Lipopolysaccharide”, J. Exp. Med., vol. 176, pp. 1665-1671 ( Dec. 1992).
Affolter Michael
Labeta Mario
Schiffrin Eduardo
Bell Boyd & Lloyd LLP
Hamud Fozia
Mertz Prema
Nestec S.A.
LandOfFree
Soluble toll-like receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Soluble toll-like receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Soluble toll-like receptor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3852913