Soluble T-cell antigen receptor chimeric antigens

Details Soluble T-cell antigen receptor chimeric antigens Soluble T-cell antigen receptor chimeric antigens

1990-01-12

1993-06-01

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530402, 530403, 424 88, 435 697, C07K 1528, A61K 39385, C12P 2102

Patent

active

052161323

ABSTRACT:
Soluble antigens useful for efficient production of antibodies against human T-cell receptor epitopes are provided. A preferred antigen is a chimeric polypeptide comprising at least 100 amino acids from a V.beta. domain with solubility conferred by an immunoglobulin heavy chain CH2 or CH3 domain fused thereto. Product antibodies and methods for diagnostic and therapeutic uses for both antigens and antibodies are provided.

REFERENCES:
patent: 4886743 (1989-12-01), Hood et al.
patent: 4923799 (1990-05-01), Mak
patent: 5116964 (1992-05-01), Capon et al.
Mariuzza et al., Journal of Biological Chemistry 264: 7310-7316, May 5, 1989.
Gascoigne et al., Proc. Natl. Acad. Sci. 84: 2936-2940, May 1987.
Becker et al., Cell 58: 911-921, Sep. 8, 1989.

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