Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2005-04-05
2005-04-05
Ketter, James (Department: 1636)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C530S300000, C530S345000
Reexamination Certificate
active
06875611
ABSTRACT:
Amphiphilic lipopeptide compositions for gene delivery are disclosed. An illustrative amphiphilic lipopeptide composition includes a human protamine 2 peptide conjugated to a hydrophobic moiety. Illustrative hydrophobic moieties include sterols, bile acids, and fatty acids. The amphiphilic lipopeptide composition is mixed with a nucleic acid such that the nucleic acid binds to the peptide portion of the lipopeptide. This mixture is placed in contact with mammalian cells to effect transfection of the cells with the nucleic acid. A method of making such amphiphilic lipopeptides is also described.
REFERENCES:
patent: 6008202 (1999-12-01), Huang et al.
Benimetskaya et al., Bioconjugate Chemistry, vol. 13, 2002, pp. 177-187.*
Cotten et al. “Transferrin-polycation-mediated introduction of DNA into human leukemic cells: Stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels,” Proc. Natl. Acad. Sci. USA, 87: 4033-4037, Jun. 1990.
Han et al. “Water-Soluble Lipopolymer for Gene Delivery,” Bioconjugate Chem., 12: 337-345, 2001.
Kim Sung Wan
Mahato Ram I.
Maheshwari Anurag
Clayton Howarth & Cannon, P.C.
Ketter James
University of Utah Research Foundation
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