Soluble salts of ibuprofen and naproxen with N-(2-hydroxyethyl)

Details Soluble salts of ibuprofen and naproxen with N-(2-hydroxyethyl) Soluble salts of ibuprofen and naproxen with N-(2-hydroxyethyl)

1992-06-23

1993-04-27

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548474, 562466, 562496, A61K 3140, C07D20706

Patent

active

052062627

ABSTRACT:
The salts, in the crystalline form, of ibuprofen and naproxen with N-(2-hydroxyethyl) pyrrolidine are prepared by dissolving ibuprofen and naproxen respectively in a suitable organic solvent, by adding N-(2-hydroxyethyl) pyrrolidine, by letting the compounds react, by removing the solvent and by crystallizing the obtained salt from a solution in an apolar and aprotic solvent.
Said salts have a high solubility in water and are used for preparing pharmaceutic compositions for oral and other administrations.

REFERENCES:
patent: 3637767 (1972-01-01), Alvarez
patent: 4948805 (1990-08-01), Ziggiotti et al.
patent: 4994604 (1991-02-01), Tung et al.
patent: 5019563 (1991-05-01), Hunter et al.
patent: 5028625 (1991-07-01), Motola et al.

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