Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1995-05-15
1998-06-23
Degen, Nancy
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
4351723, 4353201, C12N 121, C12N 1563, C12N 1570
Patent
active
057704341
ABSTRACT:
A method of synthesizing isolated, soluble peptides having constrained secondary structure in solution is described herein. The peptides are encoded by expressible oligonucleotides having a desirable bias of random codon sequences.
REFERENCES:
patent: 4458066 (1984-07-01), Caruthers et al.
patent: 4771000 (1988-09-01), Verrips et al.
patent: 5185147 (1993-02-01), Papsidero
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5270163 (1993-12-01), Gold et al.
patent: 5403484 (1995-04-01), Ladner et al.
patent: 5427908 (1995-06-01), Dower et al.
patent: 5432018 (1995-07-01), Dower et al.
Fieser (1987) PNAS, USA 84, 8568-8572.
Schulze-Gahmen (1985). EMBO 4(7), 1731-1737.
McCormick et al (1987) J. Immunol. 139(8), 2615-2619.
Jemmerson, Ronald and Hutchinson, Robert M. "Fiine Manipulation of Antibody Affinity for Synthetic Epitopes by Altering Peptide Structure: Antibody Binding to Looped Peptides." Eur. J. Immunol. 20:579-585 (1990).
Zuckermann, Ronald N. et al. "Identification of Highest-Affinity Ligands by Affinity Selection From Equimolar Peptide Mixtures Generated by Robotic Synthesis." Proc. Natl. Acad. Sci. USA. 89:4505-4509 (1992).
Jaynes et al., "Construction and Expression of Synthetic DNA Fragments Coding for Polypeptides with Elevated Levels of Essential Amino Acids". Appl. Microbiol. Biotechnol. 21:200-205 (1985).
Oliphant et al., "Cloning of Random-Sequence Oligodeoxynucleotides". Gene 44:177-183 (1986).
Winnaker, Ernst-Ludwig, "From Genes to Clones: Introduction to Gene Technology", Translated by Horst Ibelhaufts. Weinheim, New York, VCH, 1987.
Marvin and Wachtel, "Structure and Assembly of Filamentous Bacterial Viruses". Nature 253:19-23 (1975).
Smith, G., "Filamentous Fusion Phage: Novel Expression Vectors that Display Cloned Antigens on the Virion Surface". Science 228:1315-1317 (1985).
Parmley and Smith, "Antibody-selectable Filamentous FD Phage Vectors: Affinity Purfication of Target Genes". Gene 73:305-318 (1988).
Scott and Smith, "Searching for Peptide Ligands with an Epitope Library". Science 249:386-390 (1990).
Devlin et al., "Random Peptide Libraries: a Source of Specific Protein Binding Molecules". Science 249:404-406 (1990).
Cwirla et al., "Peptides on Phage: a Vast Library of Peptides for Identifying Ligands". Proc. Natl. Acad. Sci. USA 87:6378-6382 (1990).
Olivera, Baldomero et al., "Conotoxins." J. Biol. Chem. 266:22067-22070 (1991).
Gallusser, Andreas and Kuhn, Andreas, Initial Steps in Protein membrane Insertion. Bacterophage M13 Procoat Protein Binds to the Membrane Surface by Electrostatic Interaction. EMBO J. 9:2723-2729.
Akiyama,Yoshinori and Ito, Koreaki The SecY Membrane Component of the Bacterial Protein Export Machinery: Analysis by New Electrophoretic Methods for Integral Membrane Proteins. EMBO J. 4:3351-3356 (1985).
Lill, Roland et al., "The Trigger Factor Cycle Includes Ribosomes, Prescretory Proteins, and the Plasma Membrane." Cell 54:1013-1018 (1988).
Wolfe, Paul B. et al., "Effects of Two sec Genes on Protein Assembly into the Plasma Membrane of Escherichia coli." 260:1836-1841 (1985).
Kuhn, Andreas "alterations in the Extracellular Domain of M13 Procoat Protein Make its Membrane Insertion Dependent on secA and SecY." Eur. J. Biochem. 177:267-271 (1988).
Degen Nancy
IXSYS Incorporated
Schwartzman Robert
LandOfFree
Soluble peptides having constrained, secondary conformation in s does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Soluble peptides having constrained, secondary conformation in s, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Soluble peptides having constrained, secondary conformation in s will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1393698