Chemistry: molecular biology and microbiology – Vector – per se
Patent
1996-07-31
1999-02-23
Crouch, Deborah
Chemistry: molecular biology and microbiology
Vector, per se
4351723, 514 44, 530395, 935 52, C12N 500, C12N 1500, A61K 4800, C07K 100
Patent
active
058742972
ABSTRACT:
A targetable gene delivery system is provided for introducing foreign genes into mamallian cells. The system employs a soluble targetable DNA complex and utilizes receptor-mediated endocytosis to endow cell specificity. The soluble DNA-carrying complex is formed by non-covalently binding a ligand conjugate with the foreign gene. The conjugate, in turn, is formed by bonding receptor-specific ligands such as asialoglycoproteins to polycations such as polylysine through covalent bonds such as disulfide bonds. The system exhibits a high degree of cell specificity and offers potential for the treatment of inherited genetic disorders.
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Wu Catherine H.
Wu George Y.
Crouch Deborah
DeConti, Jr. Giulio A.
Remillard Jane E.
University of Connecticut
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