Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations
Patent
1993-02-11
1997-04-08
Dodson, Shelley A.
Drug, bio-affecting and body treating compositions
Topical sun or radiation screening, or tanning preparations
424 60, 514937, 514938, 514939, 514969, A61K 742, A61K 740, A61K 906
Patent
active
056185197
ABSTRACT:
A melanin that is soluble in an aqueous solution at a pH of at least 5 to 9 at a temperature of 0.degree. to 100.degree. C. The melanin is further characterized by being capable of being filtered through at least a 0.45 micron size filter. Still further, the melanin is characterized by having a molecular weight of greater than 10,000 kilodaltons. The melanin is useful for providing a naturally-appearing tan to mammalian skin and hair. Such melanin can be produced by combining dopachrome and 5,6-dihydroxyindole (or allowing dopachrome to spontaneously form 5,6-dihydroxyindole) and an appropriate enzyme or by combining 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid or by incubating 5,6-dihydroxyindole-2-carboxylic acid alone. The melanin is also useful for providing a sun-screen to mammalian skin and hair.
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Biochemical et Biophysica Acta 925 (1987) 203-209, "Effect of Metal Ions on the Rearrangement of Dopachrome".
Orlow Seth J.
Pawelek John M.
Dodson Shelley A.
Yale University
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