Soluble melanin

Details Soluble melanin Soluble melanin

1991-03-25

1993-07-06

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

424 59, 424 63, A61K 31405

Patent

active

052254356

ABSTRACT:
A melanin that is soluble in an aqueous solution at a pH of at least 5 to 9 at a temperature of 0 to 100.degree. C. The melanin is further characterized by being capable of being filtered through at least a 0.45 micron size filter. Still further, the melanin is characterized by having a molecular weight of greater than 10,000 kilodaltons. The melanin is useful for providing a naturally-appearing tan to mammalian skin and hair. Such melanin can be produced by combining dopachrome and 5,6-dihydroxyindole (or allowing dopachrome to spontaneously form 5,6-dihydroxyindole) and an appropriate enzyme or by combining 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid or by incubating 5,6-dihydroxyindole-2-carboxylic acid alone. The melanin is also useful for providing a sun-screen to mammalian skin and hair, to treat post-inflammatory hypo- and hyperpigmentation, to tint glass and plastic, to protect industrial materials against ultraviolet damage, and as a coloring agent in foodstuffs such as coffee, tea, soda, whiskey and liquors.

REFERENCES:
patent: 4515773 (1985-05-01), Herlihy
patent: 4968497 (1990-11-01), Wolfram et al.
Korner & Pawelek, BA81(1): 5362 (1985).
Korner & Gettins, BA71(1): 3755 (1980).

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