Soluble mammalian adenylyl cyclase and uses therefor

Details Soluble mammalian adenylyl cyclase and uses therefor Soluble mammalian adenylyl cyclase and uses therefor

1996-10-04

2000-08-22

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Lyase

435 671, 435 697, 4352523, 4353201, 536 232, 536 234, 536 235, 935 14, 935 29, 935 32, 935 47, C12N 988, C12N 1560, C12N 1562, C12N 1585

Patent

active

061070769

ABSTRACT:
A soluble form of adenylyl cyclase and methods of its use in screening for stimulators and inhibitors of adenylyl cyclase activity are disclosed. In one embodiment, a chimera of type I and type II adenylyl cyclases is provided. This chimera lacks transmembrane domains characteristic of adenylyl cyclases, rendering the recombinant product soluble, while retaining adenylyl cyclase function.

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