Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-04-15
1996-05-28
Walsh, Stephen G.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352351, 4352401, 4351721, 4352402, 435 696, 530350, 530413, C12P 2102, C12N 1509, C07K 14705
Patent
active
055210716
ABSTRACT:
A truncation of the human LDL receptor gene has been created which can be expressed in a heterologous host to produce a soluble fragment to the receptor protein. The gene can be expressed in insect cells in culture to produce a protein fragment which is not only water soluble but which also retains affinity for binding to LDL. The truncation is a truncation of the carboxyl terminus of the native LDL receptor gene which results in a 354 amino acid protein fragment designated LDL-R.sup.354.
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Attie Alan D.
Gretch Daniel G.
Sturley Stephen L.
Teng Sally P.
Walsh Stephen G.
Wisconsin Alumni Research Foundation
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