Induced nuclear reactions: processes – systems – and elements – Nuclear transmutation – By neutron bombardment
Patent
1989-10-02
1991-10-01
Wasil, Daniel D.
Induced nuclear reactions: processes, systems, and elements
Nuclear transmutation
By neutron bombardment
376158, 250432PD, 423 2, G21G 100
Patent
active
050531867
ABSTRACT:
Water soluble irradiation targets are disclosed for the production of .sup.186 Re and .sup.188 Re. The irradiation targets are selected for both water solubility and absence of elements which would produce contaminating isotopes for medical therapeutic and diagnostic use. In one embodiment, .sup.186 Re or .sup.188 Re is produced by the direct irradiation of a water soluble irradiation target comprising .sup.185 Re or .sup.187 Re, respectively. Preferred targets for this purpose include aluminum perrhenate, lithium perrhenate and magnesium perrhenate. In another embodiment, a zirconyl tungstate generator comprising .sup.188 W for the production of .sup.186 Re is obtained by irradiating a soluble irradiation target comprising .sup.186 W, dissolving the irradiated target in aqueous solution, reacting the dissolved target with an aqueous solution comprising zirconyl ion to form an insoluble zirconium tungstate precipitate and disposing the precipitate in an elutable container. Preferred irradiation targets for this purpose include sodium tungstate and lithium tungstate. In each of the foregoing embodiments, the irradiation target is readily soluble in aqueous solution and may be used directly in solution form after irradiation, such as for ligand conjunction for medical diagnostic or therapeutic purposes, without cumbersome dissolution, neutralization, purification and other processing steps involving irradiated materials inherent in prior .sup.186 Re and .sup.188 Re production methods.
REFERENCES:
patent: 3324005 (1967-06-01), Miller
patent: 3332737 (1967-07-01), Kraus
patent: 4278641 (1981-07-01), Petrov et al.
patent: 4280053 (1981-07-01), Evans et al.
patent: 4738834 (1988-04-01), Moore et al.
patent: 4778672 (1988-10-01), Deutsch et al.
patent: 4839467 (1989-06-01), Deutsch
patent: 4859431 (1989-08-01), Ehrhardt
patent: 4990787 (1991-02-01), Vanderheyden et al.
M. B. Varfolomeey et al., "Aluminium and Gallium Perrhenate Heptahydrates", Russian Journal of Inorganic Chemistry 14(1), 35-38, 1969.
L. L. Zaitseva et al., "Physicochemical Properties of Aluminium Pertechnetate and Aluminium Perrhenate", Russian Journal of Inorganic Chemistry 31(6), 816-818, 1986.
Evans, J. et al., "Zirconium Molybdate Gel as a Generator for Technetium-99m--I. The Concept and its Evaluation", Appl. Radiat. Isot. 38(1), 19-23, 1987, Int. J. Radiat. Appl. Instrum. Part A.
Moore, P. W. et al., "Zirconium Molybdate Gel as a Generator for Technetium-99m--II. High Activity Generators", Appl. Radiat. Isot. 38(1), 25-29, 1987, Int. J. Radiat. Appl. Instrum. Part B.
Blachot, J. et al., "Un Generateur de .sup.188 Re a Partir de .sup.188 W", International Journal of Applied Radiation and Isotopes 20, 467-470, 1969.
Kordyukevich, V. O. et al., "Extractive Separation of Rhenium Isotopes Without Carriers from a Tungsten Target", Radiokhimya 26(5), 625-629, 1984.
Evans, J. V. et al., "A New Generator for Technetium-99m", purportedly presented at 3rd World Congress Nuclear Medicine & Biology, Paris, Aug. 1982.
Narasimhan, D. V. S. et al., "A New Method for .sup.99m Tc Generator Preparation", J. Radioanal. Nucl. Chem. Letters 85(6), 345-355, 1984.
Narasimhan, D. V. S. et al., "Preparation of a Sterile Closed System .sup.99m Tc Generator Based on Zirconium Molybdate", J. Radioanal. Nucl. Chem. Letters 85(3), 163-172, 1984.
Boyd, R. E., "Technetium-99m Generators--The Available Options", Int. J. Appl. Radiat. Isot. 33, 801-809, 1982.
Deutsch, E. et al., "The Chemistry of Rhenium and Technetium as Related to the Use of Isotopes of these Elements in Therapeutic and Diagnositc Nuclear Medicine", Nucl. Med. Biol. 13(4): 465-477, 1986, Int. J. Radiat. Appl. Instrum., Part B.
Britton, H. T. S. and German, W. L., "CXCIII.--Physicochemical Studies of Complex Acids. Part VI. The Precipitation of Molybdates", pp. 1429-1435, 1931.
Ryabchikov, D. et al., "Chromatographic Separation of Rhenium from Molybdenum and Tungsten by Means of Mixed Eluents on EDE-10 Anion Exchange Resin", translated from Zhurnal Analiticheskol Khimii 17, 890-892, 1962.
Pinagian, J., "A Technetium-99m Generator Using Hydrous Zirconium Oxide", Internatl. J. of Applied Radiation and Isotopes 17, 664-666, 1966.
Plotnikov, V. et al., "Separation of Small Amounts of Rhenium and Tungsten by Means of Zirconium Hydroxide", translated from Zhurnal Analiticheskol Khimii 21, 1260-1262, 1966.
Lewis, R. et al., "Production of 70-Day Tungsten-188 and Development of a 17 Hour Rhenium-188 Radioisotope Generator", J. Nucl. Med. 7, 804-805, 1966.
Meloni, S. et al., "A New Technetium-99m Generator Using Manganese Dioxide", Internatl. J. of Applied Radiation and Isotopes 19, 164-166, 1968.
Klofutar, C. et al., "Radiochemical Separation of Rhenium (VII) from Tungsten (VI)", Journal of Radioanalytical Chemistry 5, 3-10, 1970.
Malyshev, K. V. et al., "Generator of Rhenium-188 Based on Hydrated Zirconium Oxide", translated from Radiokhimiya 17, 249-251, 1975.
Tanase, M., "Separaton of .sup.99m Tc from Neutron-Irradiated MoO.sub.3 by Precipitation as CaMoO.sub.4 ", Journal of Radioanalytical Chemistry 41, 23-27, 1977.
Ehrhardt, G. J. et al., abstract No. 416 entitled, "An Improved Tungsten-188/Rhenium-188 Generator for Radiotherapeutic Applications", Journal of Nuclear Medicine (Proceedings of the 34th Annual Meeting), 28(4), 656-657, 1987.
Ehrhardt Gary J.
Su Fu-Min
Vanderheyden Jean-Luc E.
NeoRx Corporation
The Curators of the University of Missouri
Wasil Daniel D.
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