Soluble Interleukin-20 receptor

Details Soluble Interleukin-20 receptor Soluble Interleukin-20 receptor

2006-10-17

2006-10-17

O'Hara, Eileen B. (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Lymphokines, e.g., interferons, interlukins, etc.

C435S069100, C435S069700, C536S023500

Reexamination Certificate

active

07122632

ABSTRACT:
A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.

REFERENCES:
patent: 6020163 (2000-02-01), Conklin
patent: WO99/07740 (1999-02-01), None
patent: WO99/46379 (1999-09-01), None
patent: WO00/39161 (2000-07-01), None
Stefan Rose-John; Interleukin-6 biology is coordinated by membrane bound and soluble receptors. Acta biochimica Polonica, vol. 50, No. 3, pp. 603-611, 2003.
Robinson et al. Optimizing the Stability of Single-Chain Proteins by Linker Length and Composition Mutagenesis. Proceedings of National Academey Science, vol. 95, pp. 5929-5934, May 1998.
Blumberg, H. et al., Cell 104:9-19, 2001.
Rich, B.E. and Kupper, T.S., Current Biol. 11: R531-R534, 2001.

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