Soluble IL-17RA/RC fusion proteins and related methods

Details Soluble IL-17RA/RC fusion proteins and related methods Soluble IL-17RA/RC fusion proteins and related methods

2010-06-30

2011-12-27

Jiang, Dong (Department: 1646)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S252300, C435S325000, C536S023100, C530S350000

Reexamination Certificate

active

08084231

ABSTRACT:
Disclosed are antagonists of IL-17A and IL-17F. The antagonists are based on soluble IL-17RA and IL-17RC fusion proteins, including hybrid soluble receptors comprising portions of both IL-17RC and IL-17RA (“IL-17RC/IL-17RA”). Such antagonists serve to block, inhibit, reduce, antagonize or neutralize the activity of IL-17F, IL-17A, or both IL-17A and IL-17F. Also disclosed are methods of using such antagonists for treating disease, particularly inflammatory diseases mediated at least in part by IL-17A and/or IL-17F.

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