Soluble hirudin conjugates

Details Soluble hirudin conjugates Soluble hirudin conjugates

1990-10-04

1992-05-12

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

420422, 514 2, 514 8, 523112, 523113, 530300, 530382, 530395, 530402, 530810, 530812, 530813, A61F 200, A61K 3100, C07K 300

Patent

active

051126150

ABSTRACT:
Disclosed is a soluble, biocompatible, pharmacological agent for inhibiting thrombin generation and thrombus formation, and methods for producing the same. The pharmacological agent or conjugate includes a soluble, biocompatible carrier and a thrombogenesis inhibitor immobilized thereto via the carrier which binds the inhibitor. The thrombogenesis inhibitor is hirudin, or an active analog or active fragment thereof. The thrombogenesis inhibitor may be bound to the carrier via a bifunctional cross-linking reagent.

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Biopharm (UK) Limited.

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