Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-12-22
2010-12-14
Kemmerer, Elizabeth C. (Department: 1646)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S069700, C435S325000, C435S348000, C435S252300, C435S254110, C435S320100, C536S023100, C536S023400, C536S023500, C530S350000, C530S351000, C514S002600
Reexamination Certificate
active
07851182
ABSTRACT:
A polypeptide-dimer built of two identical monomeric fragments comprising the domains 1 to 3 of the extracellular (soluble) part of glycoprotein (gp)130 and a certain polypeptide spacer are described, which are covalently linked with each other and which bear significant advantages concerning their production rate in host cells, their improved purification and their potential to bind to IL-6/soluble IL-6 receptor complexes. Furthermore, a pharmaceutical composition containing said dimeric molecule and various medical uses are described.
REFERENCES:
patent: 7534862 (2009-05-01), Seegert et al.
patent: 7629147 (2009-12-01), Seegert et al.
patent: 2002/0169292 (2002-11-01), Weintraub et al.
patent: 1148065 (2001-10-01), None
patent: 1491554 (2004-12-01), None
patent: WO94/12520 (1994-06-01), None
Chow, Dar-Chone, et al., “A structural template for gp130-cytokine signaling assemblies”, Biochimica et Biophysica Acta, vol. 1592, No. 3, Nov. 11, 2002, pp. 225-235.
Giese, Bernd, et al., “Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells”, Journal of Cell Science, vol. 118, No. 21, Nov. 2005, pp. 5129-5140.
Ward, Larry D., et al., “Influence of Interleukin-6 (IL-6) Dimerization on Formation of the High Affinity Hexameric IL-6 Receptor Complex”, The Journal of Biological Chemistry, vol. 271, No. 33, Aug. 16, 1996, pp. 20138-20144.
International Search Report for PCT/EP2006/012515, mailed May 4, 2007.
Seegert Dirk
Waetzig Georg H.
Conaris Research Institute AG
Howrey LLP
Kemmerer Elizabeth C.
Kung Viola T.
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