Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Reexamination Certificate
2011-01-18
2011-01-18
Nashed, Nashaat T (Department: 1656)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
C435S201000
Reexamination Certificate
active
07871607
ABSTRACT:
The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
REFERENCES:
patent: 3536809 (1970-10-01), Applezweig
patent: 3598123 (1971-08-01), Zaffaroni
patent: 3630200 (1971-12-01), Higuchi
patent: 3710795 (1973-01-01), Higuchi et al.
patent: 3845770 (1974-11-01), Theeuwes et al.
patent: 3916899 (1975-11-01), Theeuwes et al.
patent: RE28819 (1976-05-01), Thompson
patent: 4002531 (1977-01-01), Royer
patent: 4008719 (1977-02-01), Theeuwes et al.
patent: 4044126 (1977-08-01), Cook et al.
patent: 4179337 (1979-12-01), Davis et al.
patent: 4328245 (1982-05-01), Yu et al.
patent: 4358603 (1982-11-01), Yu
patent: 4364923 (1982-12-01), Cook et al.
patent: 4409239 (1983-10-01), Yu
patent: 4410545 (1983-10-01), Yu et al.
patent: 4414209 (1983-11-01), Cook et al.
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 4687610 (1987-08-01), Vassilatos
patent: 4769027 (1988-09-01), Baker et al.
patent: 4820516 (1989-04-01), Sawyer et al.
patent: 4952496 (1990-08-01), Studier et al.
patent: 4980286 (1990-12-01), Morgan et al.
patent: 5041292 (1991-08-01), Feijen
patent: 5052558 (1991-10-01), Carter
patent: 5059595 (1991-10-01), Le Grazie
patent: 5073543 (1991-12-01), Marshall et al.
patent: 5120548 (1992-06-01), McClelland et al.
patent: 5122614 (1992-06-01), Zalipsky
patent: 5183550 (1993-02-01), Mattiessen
patent: 5215899 (1993-06-01), Dattagupta
patent: 5292509 (1994-03-01), Hageman
patent: 5323907 (1994-06-01), Kalvelage
patent: 5324844 (1994-06-01), Zalipsky
patent: 5354566 (1994-10-01), Addesso et al.
patent: 5436128 (1995-07-01), Harpold et al.
patent: 5446090 (1995-08-01), Harris
patent: 5591767 (1997-01-01), Mohr et al.
patent: 5612460 (1997-03-01), Zalipsky
patent: 5631018 (1997-05-01), Zalipsky et al.
patent: 5639476 (1997-06-01), Oshlack et al.
patent: 5643575 (1997-07-01), Martinez et al.
patent: 5665069 (1997-09-01), Cumer et al.
patent: 5672662 (1997-09-01), Harris et al.
patent: 5674533 (1997-10-01), Santus et al.
patent: 5714166 (1998-02-01), Tomalia et al.
patent: 5721348 (1998-02-01), Primakoff et al.
patent: 5723147 (1998-03-01), Kim et al.
patent: 5733566 (1998-03-01), Lewis
patent: 5747027 (1998-05-01), Stern et al.
patent: 5766581 (1998-06-01), Bartley et al.
patent: 5766627 (1998-06-01), Sankaram et al.
patent: 5795569 (1998-08-01), Bartley et al.
patent: 5808096 (1998-09-01), Zalipsky
patent: 5827721 (1998-10-01), Stern et al.
patent: 5854046 (1998-12-01), Au-Young et al.
patent: 5900461 (1999-05-01), Harris
patent: 5919455 (1999-07-01), Greenwald et al.
patent: 5932462 (1999-08-01), Harris et al.
patent: 5958750 (1999-09-01), Au-Young et al.
patent: 5985263 (1999-11-01), Lee et al.
patent: 5990237 (1999-11-01), Bentley et al.
patent: 6057110 (2000-05-01), Au-Young et al.
patent: 6103525 (2000-08-01), Stern et al.
patent: 6113906 (2000-09-01), Greenwald et al.
patent: 6123938 (2000-09-01), Stern et al.
patent: 6184023 (2001-02-01), Hashimoto et al.
patent: 6193963 (2001-02-01), Stern et al.
patent: 6214966 (2001-04-01), Harris
patent: 6258351 (2001-07-01), Harris
patent: 6340742 (2002-01-01), Burg et al.
patent: 6413507 (2002-07-01), Bentley et al.
patent: 6420339 (2002-07-01), Gegg et al.
patent: 6437025 (2002-08-01), Harris et al.
patent: 6448369 (2002-09-01), Bentley et al.
patent: 6461802 (2002-10-01), Van Thillo et al.
patent: 6495659 (2002-12-01), Bentley et al.
patent: 6552170 (2003-04-01), Thompson et al.
patent: 6682904 (2004-01-01), Frost
patent: 6737505 (2004-05-01), Bentley et al.
patent: 6828401 (2004-12-01), Nho et al.
patent: 6828431 (2004-12-01), Frudakis et al.
patent: 6858736 (2005-02-01), Nho et al.
patent: 7105330 (2006-09-01), Stern et al.
patent: 7148201 (2006-12-01), Stern et al.
patent: 7368108 (2008-05-01), DeFrees et al.
patent: 7544499 (2009-06-01), Frost et al.
patent: 2001/0021763 (2001-09-01), Harris
patent: 2001/0044526 (2001-11-01), Shen
patent: 2001/0046481 (2001-11-01), Bentley et al.
patent: 2002/0052430 (2002-05-01), Harris et al.
patent: 2002/0072573 (2002-06-01), Bentley et al.
patent: 2002/0156047 (2002-10-01), Zhao
patent: 2003/0114647 (2003-06-01), Harris et al.
patent: 2003/0143596 (2003-07-01), Bentley et al.
patent: 2003/0158333 (2003-08-01), Roberts et al.
patent: 2003/0170243 (2003-09-01), Stern et al.
patent: 2003/0220447 (2003-11-01), Harris
patent: 2004/0013637 (2004-01-01), Bentley et al.
patent: 2004/0096921 (2004-05-01), Stern et al.
patent: 2004/0157787 (2004-08-01), Or et al.
patent: 2004/0224012 (2004-11-01), Suvanprakorn et al.
patent: 2004/0224023 (2004-11-01), Hunter et al.
patent: 2004/0268425 (2004-12-01), Bookbinder et al.
patent: 2005/0002865 (2005-01-01), Klaveness et al.
patent: 2005/0004095 (2005-01-01), Glinka et al.
patent: 2005/0114037 (2005-05-01), Desjarlais et al.
patent: 2005/0171328 (2005-08-01), Harris
patent: 2005/0209416 (2005-09-01), Harris
patent: 2005/0287134 (2005-12-01), Klein
patent: 2006/0104968 (2006-05-01), Bookbinder et al.
patent: 2007/0134228 (2007-06-01), Stern et al.
patent: 2007/0148156 (2007-06-01), Frost et al.
patent: 2009/0123367 (2009-05-01), Bookbinder et al.
patent: 2009/0181013 (2009-07-01), Bookbinder et al.
patent: 2009/0181032 (2009-07-01), Bookbinder et al.
patent: 2009/0214505 (2009-08-01), Bookbinder et al.
patent: 2009/0253175 (2009-10-01), Bookbinder et al.
patent: 2009/0304665 (2009-12-01), Frost et al.
patent: 2009/0311237 (2009-12-01), Frost
patent: 2010/0003237 (2010-01-01), Keller et al.
patent: 2010/0003238 (2010-01-01), Frost et al.
patent: 2010/0074885 (2010-03-01), Schiff et al.
patent: 013420 (1980-07-01), None
patent: 0400472 (1996-04-01), None
patent: 0822199 (2004-09-01), None
patent: 01064951 (2007-08-01), None
patent: 6-153947 (1994-03-01), None
patent: 6-503721 (1994-04-01), None
patent: WO 88/02261 (1988-04-01), None
patent: WO 88/09810 (1988-12-01), None
patent: WO 89/10134 (1989-11-01), None
patent: WO 90/11364 (1990-10-01), None
patent: WO 92/06180 (1992-04-01), None
patent: WO 92/10569 (1992-06-01), None
patent: WO 92/16640 (1992-10-01), None
patent: WO 92/20316 (1992-11-01), None
patent: WO 92/22635 (1992-12-01), None
patent: WO 93/14188 (1993-07-01), None
patent: WO 93/20221 (1993-10-01), None
patent: WO 94/08598 (1994-04-01), None
patent: WO 94/28024 (1994-12-01), None
patent: WO 96/31596 (1996-10-01), None
patent: WO 98/16655 (1998-04-01), None
patent: WO 99/29841 (1999-06-01), None
patent: WO 99/32619 (1999-07-01), None
patent: WO 00/02017 (2000-01-01), None
patent: WO 01/87925 (2001-04-01), None
patent: WO 01/76640 (2001-10-01), None
patent: WO 01/29058 (2001-11-01), None
patent: WO 02/49673 (2002-06-01), None
patent: WO 2004/058147 (2004-07-01), None
patent: WO 2004/078140 (2004-09-01), None
patent: WO 2006/091871 (2006-08-01), None
patent: WO 2009/111066 (2009-09-01), None
patent: WO 2009/111083 (2009-09-01), None
patent: WO 2009/117085 (2009-09-01), None
patent: WO 2009/128917 (2009-10-01), None
patent: WO 2009/128918 (2009-10-01), None
patent: WO 2009/134380 (2009-11-01), None
Adams et al., “The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice,” Nature 318:533-538 (1985).
Alexander et al., “Expression of the c-myc oncogene under control of an immunoglobulin enhancer in E mu-myc transgenic mice,&#x
Bookbinder Louis H.
Frost Gregory I.
Kundu Anirban
Halozyme, Inc.
K & L Gates LLP
Nashed Nashaat T
Seidman Stephanie
LandOfFree
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